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Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma

AIM: To evaluate whether pathologically early hepatocellular carcinoma (HCC) exhibited local tumor progression after radiofrequency ablation (RFA) less often than typical HCC. METHODS: Fifty pathologically early HCCs [tumor diameter (mm): mean, 15.8; range, 10-23; follow-up days after RFA: median, 1...

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Autores principales: Hao, Yoshiteru, Numata, Kazushi, Ishii, Tomohiro, Fukuda, Hiroyuki, Maeda, Shin, Nakano, Masayuki, Tanaka, Katsuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423048/
https://www.ncbi.nlm.nih.gov/pubmed/28533668
http://dx.doi.org/10.3748/wjg.v23.i17.3111
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author Hao, Yoshiteru
Numata, Kazushi
Ishii, Tomohiro
Fukuda, Hiroyuki
Maeda, Shin
Nakano, Masayuki
Tanaka, Katsuaki
author_facet Hao, Yoshiteru
Numata, Kazushi
Ishii, Tomohiro
Fukuda, Hiroyuki
Maeda, Shin
Nakano, Masayuki
Tanaka, Katsuaki
author_sort Hao, Yoshiteru
collection PubMed
description AIM: To evaluate whether pathologically early hepatocellular carcinoma (HCC) exhibited local tumor progression after radiofrequency ablation (RFA) less often than typical HCC. METHODS: Fifty pathologically early HCCs [tumor diameter (mm): mean, 15.8; range, 10-23; follow-up days after RFA: median, 1213; range, 216-2137] and 187 typical HCCs [tumor diameter (mm): mean, 15.6; range, 6-30; follow-up days after RFA: median, 1116; range, 190-2328] were enrolled in this retrospective study. The presence of stromal invasion (namely, tumor cell invasion into the intratumoral portal tracts) was considered to be the most important pathologic finding for the diagnosis of early HCCs. Typical HCC was defined as the presence of a hyper-vascular lesion accompanied by delayed washout using contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. Follow-up examinations were performed at 3-mo intervals to monitor for signs of local tumor progression. The local tumor progression rates of pathologically early HCCs and typical HCCs were then determined using the Kaplan-Meier method. RESULTS: During the follow-up period for the 50 pathologically early HCCs, 49 (98%) of the nodules did not exhibit local tumor progression. However, 1 nodule (2%) was associated with a local tumor progression found 636 d after RFA. For the 187 typical HCCs, 46 (24.6%) of the nodules exhibited local recurrence after RFA. The follow-up period until the local tumor progression of typical HCC was a median of 605 d, ranging from 181 to 1741 d. Among the cases with typical HCCs, local tumor progression had occurred in 7.0% (7/187), 16.0% (30/187), 21.9% (41/187) and 24.6% (46/187) of the cases at 1, 2, 3 and 4 years, respectively. Pathologically early HCC was statistically associated with a lower rate of local tumor progression, compared with typical HCC, when evaluated using a log-rank test (P = 0.002). CONCLUSION: The rate of local tumor progression for pathologically early HCCs after RFA was significantly lower than that for typical HCCs.
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spelling pubmed-54230482017-05-22 Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma Hao, Yoshiteru Numata, Kazushi Ishii, Tomohiro Fukuda, Hiroyuki Maeda, Shin Nakano, Masayuki Tanaka, Katsuaki World J Gastroenterol Retrospective Study AIM: To evaluate whether pathologically early hepatocellular carcinoma (HCC) exhibited local tumor progression after radiofrequency ablation (RFA) less often than typical HCC. METHODS: Fifty pathologically early HCCs [tumor diameter (mm): mean, 15.8; range, 10-23; follow-up days after RFA: median, 1213; range, 216-2137] and 187 typical HCCs [tumor diameter (mm): mean, 15.6; range, 6-30; follow-up days after RFA: median, 1116; range, 190-2328] were enrolled in this retrospective study. The presence of stromal invasion (namely, tumor cell invasion into the intratumoral portal tracts) was considered to be the most important pathologic finding for the diagnosis of early HCCs. Typical HCC was defined as the presence of a hyper-vascular lesion accompanied by delayed washout using contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. Follow-up examinations were performed at 3-mo intervals to monitor for signs of local tumor progression. The local tumor progression rates of pathologically early HCCs and typical HCCs were then determined using the Kaplan-Meier method. RESULTS: During the follow-up period for the 50 pathologically early HCCs, 49 (98%) of the nodules did not exhibit local tumor progression. However, 1 nodule (2%) was associated with a local tumor progression found 636 d after RFA. For the 187 typical HCCs, 46 (24.6%) of the nodules exhibited local recurrence after RFA. The follow-up period until the local tumor progression of typical HCC was a median of 605 d, ranging from 181 to 1741 d. Among the cases with typical HCCs, local tumor progression had occurred in 7.0% (7/187), 16.0% (30/187), 21.9% (41/187) and 24.6% (46/187) of the cases at 1, 2, 3 and 4 years, respectively. Pathologically early HCC was statistically associated with a lower rate of local tumor progression, compared with typical HCC, when evaluated using a log-rank test (P = 0.002). CONCLUSION: The rate of local tumor progression for pathologically early HCCs after RFA was significantly lower than that for typical HCCs. Baishideng Publishing Group Inc 2017-05-07 2017-05-07 /pmc/articles/PMC5423048/ /pubmed/28533668 http://dx.doi.org/10.3748/wjg.v23.i17.3111 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Hao, Yoshiteru
Numata, Kazushi
Ishii, Tomohiro
Fukuda, Hiroyuki
Maeda, Shin
Nakano, Masayuki
Tanaka, Katsuaki
Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma
title Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma
title_full Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma
title_fullStr Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma
title_full_unstemmed Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma
title_short Rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma
title_sort rate of local tumor progression following radiofrequency ablation of pathologically early hepatocellular carcinoma
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423048/
https://www.ncbi.nlm.nih.gov/pubmed/28533668
http://dx.doi.org/10.3748/wjg.v23.i17.3111
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