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Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients

Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemi...

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Autores principales: Mahmoodnia, Leila, Sadoughi, Maryam, Ahmadi, Ali, Kafeshani, Marzieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nickan Research Institute 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423290/
https://www.ncbi.nlm.nih.gov/pubmed/28497081
http://dx.doi.org/10.15171/jrip.2017.17
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author Mahmoodnia, Leila
Sadoughi, Maryam
Ahmadi, Ali
Kafeshani, Marzieh
author_facet Mahmoodnia, Leila
Sadoughi, Maryam
Ahmadi, Ali
Kafeshani, Marzieh
author_sort Mahmoodnia, Leila
collection PubMed
description Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemic indices, and renal function in diabetic subjects. Patients and Methods: In this cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients were recruited. Blood biochemical parameters, including fasting plasma sugar (FBS), glycosylated hemoglobin (HbA(1C)), serum uric acid (sUA), creatinine concentration and glomerular filtration rate (GFR) were measured. All statistical analysis was performed with SPSS 16.0. Results: There was a positive correlation between irisin and age (P=0.05, r=0.19) and a negative correlation between irisin and body mass index (BMI) (P=0.01, r=-0.25) was detected. There was a significant difference of serum irisin level between patients with normal and abnormal FBS too. Conclusion: In this study we found, irisin concentration was increased with age, decreased with BMI, and it was higher in subject with abnormal FBS. Thus further research is needed to provide inclusive understanding of irisin associated physiological effects and possible implications in clinical conditions.
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spelling pubmed-54232902017-05-11 Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients Mahmoodnia, Leila Sadoughi, Maryam Ahmadi, Ali Kafeshani, Marzieh J Renal Inj Prev Original Article Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemic indices, and renal function in diabetic subjects. Patients and Methods: In this cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients were recruited. Blood biochemical parameters, including fasting plasma sugar (FBS), glycosylated hemoglobin (HbA(1C)), serum uric acid (sUA), creatinine concentration and glomerular filtration rate (GFR) were measured. All statistical analysis was performed with SPSS 16.0. Results: There was a positive correlation between irisin and age (P=0.05, r=0.19) and a negative correlation between irisin and body mass index (BMI) (P=0.01, r=-0.25) was detected. There was a significant difference of serum irisin level between patients with normal and abnormal FBS too. Conclusion: In this study we found, irisin concentration was increased with age, decreased with BMI, and it was higher in subject with abnormal FBS. Thus further research is needed to provide inclusive understanding of irisin associated physiological effects and possible implications in clinical conditions. Nickan Research Institute 2016-11-20 /pmc/articles/PMC5423290/ /pubmed/28497081 http://dx.doi.org/10.15171/jrip.2017.17 Text en Copyright © 2017 The Author(s); Published by Nickan Research Institute http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mahmoodnia, Leila
Sadoughi, Maryam
Ahmadi, Ali
Kafeshani, Marzieh
Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
title Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
title_full Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
title_fullStr Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
title_full_unstemmed Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
title_short Relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
title_sort relationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423290/
https://www.ncbi.nlm.nih.gov/pubmed/28497081
http://dx.doi.org/10.15171/jrip.2017.17
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