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Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy

This case report describes the re-administration of abatacept to successfully reduce the articularsymptoms of a patient with rheumatoid arthritisduring the intensive phase of anti-tuberculous therapy. A 75-year-old man developed active pulmonary tuberculosis during the administration of abatacept fo...

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Autores principales: Kawamoto, Hironori, Takasaki, Jin, Ishii, Satoru, Suzuki, Manabu, Morino, Eriko, Naka, Go, Iikura, Motoyasu, Izumi, Shinyu, Takeda, Yuichiro, Sugiyama, Haruhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423351/
https://www.ncbi.nlm.nih.gov/pubmed/28507894
http://dx.doi.org/10.1016/j.rmcr.2017.04.013
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author Kawamoto, Hironori
Takasaki, Jin
Ishii, Satoru
Suzuki, Manabu
Morino, Eriko
Naka, Go
Iikura, Motoyasu
Izumi, Shinyu
Takeda, Yuichiro
Sugiyama, Haruhito
author_facet Kawamoto, Hironori
Takasaki, Jin
Ishii, Satoru
Suzuki, Manabu
Morino, Eriko
Naka, Go
Iikura, Motoyasu
Izumi, Shinyu
Takeda, Yuichiro
Sugiyama, Haruhito
author_sort Kawamoto, Hironori
collection PubMed
description This case report describes the re-administration of abatacept to successfully reduce the articularsymptoms of a patient with rheumatoid arthritisduring the intensive phase of anti-tuberculous therapy. A 75-year-old man developed active pulmonary tuberculosis during the administration of abatacept for rheumatoid arthritis. The patient experienced a paradoxical reaction and exacerbation of rheumatoid arthritis that caused us to discontinue the abatacept. Later re-administration of abatacept along with anti-tuberculosis treatment led to well-controlled rheumatoid arthritis without exacerbation of the tuberculosis. This case shows that re-administration of abatacept may be much safer than TNF inhibitor to treat patients who are infected with mycobacteria during thetreatment of immunological diseases such asrheumatoid arthritiswith biological agents.
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spelling pubmed-54233512017-05-15 Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy Kawamoto, Hironori Takasaki, Jin Ishii, Satoru Suzuki, Manabu Morino, Eriko Naka, Go Iikura, Motoyasu Izumi, Shinyu Takeda, Yuichiro Sugiyama, Haruhito Respir Med Case Rep Case Report This case report describes the re-administration of abatacept to successfully reduce the articularsymptoms of a patient with rheumatoid arthritisduring the intensive phase of anti-tuberculous therapy. A 75-year-old man developed active pulmonary tuberculosis during the administration of abatacept for rheumatoid arthritis. The patient experienced a paradoxical reaction and exacerbation of rheumatoid arthritis that caused us to discontinue the abatacept. Later re-administration of abatacept along with anti-tuberculosis treatment led to well-controlled rheumatoid arthritis without exacerbation of the tuberculosis. This case shows that re-administration of abatacept may be much safer than TNF inhibitor to treat patients who are infected with mycobacteria during thetreatment of immunological diseases such asrheumatoid arthritiswith biological agents. Elsevier 2017-04-15 /pmc/articles/PMC5423351/ /pubmed/28507894 http://dx.doi.org/10.1016/j.rmcr.2017.04.013 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kawamoto, Hironori
Takasaki, Jin
Ishii, Satoru
Suzuki, Manabu
Morino, Eriko
Naka, Go
Iikura, Motoyasu
Izumi, Shinyu
Takeda, Yuichiro
Sugiyama, Haruhito
Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy
title Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy
title_full Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy
title_fullStr Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy
title_full_unstemmed Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy
title_short Re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy
title_sort re-administration of abatacept for the control of articular symptoms of rheumatoid arthritis during anti-tuberculous therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423351/
https://www.ncbi.nlm.nih.gov/pubmed/28507894
http://dx.doi.org/10.1016/j.rmcr.2017.04.013
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