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The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study
PURPOSE: To assess central corneal thickness (CCT) and its associations in an adult Iranian population. METHODS: This was a population-based cross-sectional study of adults aged 40–80 years. Eyes with corneal disorders, previous ocular surgery, or trauma were excluded. All subjects underwent complet...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423366/ https://www.ncbi.nlm.nih.gov/pubmed/28540004 http://dx.doi.org/10.4103/jovr.jovr_111_15 |
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author | Soleimanizad, Reza Nowroozzadeh, Mohammad Hosein Ziaei, Hossein Pakravan, Mohammad Yaseri, Mehdi Katibeh, Marzieh |
author_facet | Soleimanizad, Reza Nowroozzadeh, Mohammad Hosein Ziaei, Hossein Pakravan, Mohammad Yaseri, Mehdi Katibeh, Marzieh |
author_sort | Soleimanizad, Reza |
collection | PubMed |
description | PURPOSE: To assess central corneal thickness (CCT) and its associations in an adult Iranian population. METHODS: This was a population-based cross-sectional study of adults aged 40–80 years. Eyes with corneal disorders, previous ocular surgery, or trauma were excluded. All subjects underwent complete ophthalmic examination, general health assessment, laboratory tests, and a detailed interview. CCT was measured with an ultrasonic pachymeter. Intraocular pressure (IOP) was measured with Goldmann applanation tonometry. Except for the report on interocular differences in CCT, only one eye of each subject was used for the rest of statistical analyses. RESULTS: The mean age (±SD) of the 1203 participants, who had CCT measurements and met inclusion criteria, was 51.8 ± 8.5 years. The mean CCT was 544 ± 35, 564 ± 28, and 544 ± 36 μm in the eyes of the normal, ocular hypertension, and glaucoma groups, respectively (P = 0.025). In participants without glaucoma, the mean interocular difference in CCT was 9 ± 12 μm. CCT was not significantly associated with age, sex, or some select systemic factors (body mass index, diabetes, hypertension, and renal failure). While controlling for age and sex, CCT was greater in individuals with higher IOPs (P < 0.001), larger vertical or horizontal cup-to-disc ratios (P = 0.044, and P = 0.025, respectively), and hyperopia (P = 0.009). CONCLUSION: In this adult Iranian population, CCT was significantly associated with IOP, cup-to-disc ratio, and the refractive status of eye. CCT outside the normal range of 475–613 μm or with interocular asymmetry greater than 33 μm (6%) should prompt evaluation for potential ocular disorders. |
format | Online Article Text |
id | pubmed-5423366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54233662017-05-24 The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study Soleimanizad, Reza Nowroozzadeh, Mohammad Hosein Ziaei, Hossein Pakravan, Mohammad Yaseri, Mehdi Katibeh, Marzieh J Ophthalmic Vis Res Original Article PURPOSE: To assess central corneal thickness (CCT) and its associations in an adult Iranian population. METHODS: This was a population-based cross-sectional study of adults aged 40–80 years. Eyes with corneal disorders, previous ocular surgery, or trauma were excluded. All subjects underwent complete ophthalmic examination, general health assessment, laboratory tests, and a detailed interview. CCT was measured with an ultrasonic pachymeter. Intraocular pressure (IOP) was measured with Goldmann applanation tonometry. Except for the report on interocular differences in CCT, only one eye of each subject was used for the rest of statistical analyses. RESULTS: The mean age (±SD) of the 1203 participants, who had CCT measurements and met inclusion criteria, was 51.8 ± 8.5 years. The mean CCT was 544 ± 35, 564 ± 28, and 544 ± 36 μm in the eyes of the normal, ocular hypertension, and glaucoma groups, respectively (P = 0.025). In participants without glaucoma, the mean interocular difference in CCT was 9 ± 12 μm. CCT was not significantly associated with age, sex, or some select systemic factors (body mass index, diabetes, hypertension, and renal failure). While controlling for age and sex, CCT was greater in individuals with higher IOPs (P < 0.001), larger vertical or horizontal cup-to-disc ratios (P = 0.044, and P = 0.025, respectively), and hyperopia (P = 0.009). CONCLUSION: In this adult Iranian population, CCT was significantly associated with IOP, cup-to-disc ratio, and the refractive status of eye. CCT outside the normal range of 475–613 μm or with interocular asymmetry greater than 33 μm (6%) should prompt evaluation for potential ocular disorders. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5423366/ /pubmed/28540004 http://dx.doi.org/10.4103/jovr.jovr_111_15 Text en Copyright: © 2017 Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Soleimanizad, Reza Nowroozzadeh, Mohammad Hosein Ziaei, Hossein Pakravan, Mohammad Yaseri, Mehdi Katibeh, Marzieh The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study |
title | The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study |
title_full | The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study |
title_fullStr | The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study |
title_full_unstemmed | The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study |
title_short | The Association of Central Corneal Thickness with Ocular and General Parameters in a Community Setting: The Yazd Eye Study |
title_sort | association of central corneal thickness with ocular and general parameters in a community setting: the yazd eye study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423366/ https://www.ncbi.nlm.nih.gov/pubmed/28540004 http://dx.doi.org/10.4103/jovr.jovr_111_15 |
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