Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

BACKGROUND: Mechanisms that inactivate the p53 pathway in Acute Myeloid Leukemia (AML), other than rare mutations, are still not well understood. METHODS: We performed a bioinformatics study of the p53 pathway function at the gene expression level on our collection of 1153 p53-pathway related genes....

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Detalles Bibliográficos
Autores principales: Abramowitz, Julia, Neuman, Tzahi, Perlman, Riki, Ben-Yehuda, Dina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423421/
https://www.ncbi.nlm.nih.gov/pubmed/28340577
http://dx.doi.org/10.1186/s12920-017-0249-2

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