Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method

OBJECTIVES: The EndoPAT method has been used as a noninvasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS: Two hundred and fifteen participants were recruited and groupe...

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Detalles Bibliográficos
Autores principales: Meeme, A, Mammen, M, Namugowa, A, Buga, GAB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2017
Materias:
Cardiovascular Topics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423431/
https://www.ncbi.nlm.nih.gov/pubmed/27196639
http://dx.doi.org/10.5830/CVJA-2016-047
Descripción
Sumario:OBJECTIVES: The EndoPAT method has been used as a noninvasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS: Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine. RESULTS: The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001). CONCLUSION: The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia.

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