Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method

OBJECTIVES: The EndoPAT method has been used as a noninvasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS: Two hundred and fifteen participants were recruited and groupe...

Descripción completa

Detalles Bibliográficos
Autores principales: Meeme, A, Mammen, M, Namugowa, A, Buga, GAB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2017
Materias:
Cardiovascular Topics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423431/
https://www.ncbi.nlm.nih.gov/pubmed/27196639
http://dx.doi.org/10.5830/CVJA-2016-047
_version_ 1783234947869310976
author Meeme, A
Mammen, M
Namugowa, A
Buga, GAB
author_facet Meeme, A
Mammen, M
Namugowa, A
Buga, GAB
author_sort Meeme, A
collection PubMed
description OBJECTIVES: The EndoPAT method has been used as a noninvasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS: Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine. RESULTS: The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001). CONCLUSION: The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia.
format Online
Article
Text
id pubmed-5423431
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Clinics Cardive Publishing
record_format MEDLINE/PubMed
spelling pubmed-54234312017-05-24 Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method Meeme, A Mammen, M Namugowa, A Buga, GAB Cardiovasc J Afr Cardiovascular Topics OBJECTIVES: The EndoPAT method has been used as a noninvasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS: Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine. RESULTS: The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001). CONCLUSION: The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia. Clinics Cardive Publishing 2017 /pmc/articles/PMC5423431/ /pubmed/27196639 http://dx.doi.org/10.5830/CVJA-2016-047 Text en Copyright © 2015 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Meeme, A
Mammen, M
Namugowa, A
Buga, GAB
Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
title Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
title_full Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
title_fullStr Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
title_full_unstemmed Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
title_short Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
title_sort endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the endopat method
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423431/
https://www.ncbi.nlm.nih.gov/pubmed/27196639
http://dx.doi.org/10.5830/CVJA-2016-047
work_keys_str_mv AT meemea endothelialdysfunctionandarterialstiffnessinpreeclampsiademonstratedbytheendopatmethod
AT mammenm endothelialdysfunctionandarterialstiffnessinpreeclampsiademonstratedbytheendopatmethod
AT namugowaa endothelialdysfunctionandarterialstiffnessinpreeclampsiademonstratedbytheendopatmethod
AT bugagab endothelialdysfunctionandarterialstiffnessinpreeclampsiademonstratedbytheendopatmethod

Ejemplares similares