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Development and Evaluation of Quality Metrics for Bioinformatics Analysis of Viral Insertion Site Data Generated Using High Throughput Sequencing

Integration of viral vectors into a host genome is associated with insertional mutagenesis and subjects in clinical gene therapy trials must be monitored for this adverse event. Several PCR based methods such as ligase-mediated (LM) PCR, linear-amplification-mediated (LAM) PCR and non-restrictive (n...

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Detalles Bibliográficos
Autores principales:	Gao, Hongyu, Hawkins, Troy, Jasti, Aparna, Chen, Yu-Hsiang, Mockaitis, Keithanne, Dinauer, Mary, Cornetta, Kenneth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423470/ https://www.ncbi.nlm.nih.gov/pubmed/28548067 http://dx.doi.org/10.3390/biomedicines2020195

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