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The role of alternative splicing in cancer
The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types. Some of these alterations have bee...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423477/ https://www.ncbi.nlm.nih.gov/pubmed/28005460 http://dx.doi.org/10.1080/21541264.2016.1268245 |
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author | Singh, Babita Eyras, Eduardo |
author_facet | Singh, Babita Eyras, Eduardo |
author_sort | Singh, Babita |
collection | PubMed |
description | The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types. Some of these alterations have been linked to tumor progression, metastasis, therapy resistance, and other oncogenic processes. Here, we describe the different mechanisms that drive splicing changes in tumors and their impact in cancer. Motivated by the current evidence, we propose a model whereby a subset of the splicing patterns contributes to the definition of specific tumor phenotypes, and may hold potential for the development of novel clinical biomarkers and therapeutic approaches. |
format | Online Article Text |
id | pubmed-5423477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-54234772017-05-17 The role of alternative splicing in cancer Singh, Babita Eyras, Eduardo Transcription Point-of-View The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types. Some of these alterations have been linked to tumor progression, metastasis, therapy resistance, and other oncogenic processes. Here, we describe the different mechanisms that drive splicing changes in tumors and their impact in cancer. Motivated by the current evidence, we propose a model whereby a subset of the splicing patterns contributes to the definition of specific tumor phenotypes, and may hold potential for the development of novel clinical biomarkers and therapeutic approaches. Taylor & Francis 2016-12-22 /pmc/articles/PMC5423477/ /pubmed/28005460 http://dx.doi.org/10.1080/21541264.2016.1268245 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Point-of-View Singh, Babita Eyras, Eduardo The role of alternative splicing in cancer |
title | The role of alternative splicing in cancer |
title_full | The role of alternative splicing in cancer |
title_fullStr | The role of alternative splicing in cancer |
title_full_unstemmed | The role of alternative splicing in cancer |
title_short | The role of alternative splicing in cancer |
title_sort | role of alternative splicing in cancer |
topic | Point-of-View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423477/ https://www.ncbi.nlm.nih.gov/pubmed/28005460 http://dx.doi.org/10.1080/21541264.2016.1268245 |
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