A link between transcription fidelity and pausing in vivo

Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss...

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Detalles Bibliográficos
Autores principales: Gamba, Pamela, James, Katherine, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423485/
https://www.ncbi.nlm.nih.gov/pubmed/28072558
http://dx.doi.org/10.1080/21541264.2016.1274812
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author Gamba, Pamela
James, Katherine
Zenkin, Nikolay
author_facet Gamba, Pamela
James, Katherine
Zenkin, Nikolay
author_sort Gamba, Pamela
collection PubMed
description Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.
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spelling pubmed-54234852017-05-17 A link between transcription fidelity and pausing in vivo Gamba, Pamela James, Katherine Zenkin, Nikolay Transcription Point-of-View Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing. Taylor & Francis 2017-01-10 /pmc/articles/PMC5423485/ /pubmed/28072558 http://dx.doi.org/10.1080/21541264.2016.1274812 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Point-of-View
Gamba, Pamela
James, Katherine
Zenkin, Nikolay
A link between transcription fidelity and pausing in vivo
title A link between transcription fidelity and pausing in vivo
title_full A link between transcription fidelity and pausing in vivo
title_fullStr A link between transcription fidelity and pausing in vivo
title_full_unstemmed A link between transcription fidelity and pausing in vivo
title_short A link between transcription fidelity and pausing in vivo
title_sort link between transcription fidelity and pausing in vivo
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423485/
https://www.ncbi.nlm.nih.gov/pubmed/28072558
http://dx.doi.org/10.1080/21541264.2016.1274812
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