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Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery
Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered po...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423570/ https://www.ncbi.nlm.nih.gov/pubmed/28529861 http://dx.doi.org/10.7150/jbji.16649 |
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author | Fleischman, Andrew N. Austin, Matthew S. |
author_facet | Fleischman, Andrew N. Austin, Matthew S. |
author_sort | Fleischman, Andrew N. |
collection | PubMed |
description | Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered powdered antibiotics have the potential to provide remarkably high intra-wound concentrations without risk for systemic toxicity. However, a paucity of high quality evidence in the orthopaedic literature has prevented widespread adoption of this technique. The majority of clinical studies on local intra-wound antibiotics have evaluated the use of topical powdered vancomycin in spinal surgery, though only a single prospective study currently exists. This review will discuss all the available evidence describing the effectiveness, pharmacokinetics, and potential adverse effects with the use of topical powdered antibiotics in orthopedic surgery. |
format | Online Article Text |
id | pubmed-5423570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-54235702017-05-19 Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery Fleischman, Andrew N. Austin, Matthew S. J Bone Jt Infect Review Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered powdered antibiotics have the potential to provide remarkably high intra-wound concentrations without risk for systemic toxicity. However, a paucity of high quality evidence in the orthopaedic literature has prevented widespread adoption of this technique. The majority of clinical studies on local intra-wound antibiotics have evaluated the use of topical powdered vancomycin in spinal surgery, though only a single prospective study currently exists. This review will discuss all the available evidence describing the effectiveness, pharmacokinetics, and potential adverse effects with the use of topical powdered antibiotics in orthopedic surgery. Ivyspring International Publisher 2017-01-01 /pmc/articles/PMC5423570/ /pubmed/28529861 http://dx.doi.org/10.7150/jbji.16649 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Fleischman, Andrew N. Austin, Matthew S. Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
title | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
title_full | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
title_fullStr | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
title_full_unstemmed | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
title_short | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
title_sort | local intra-wound administration of powdered antibiotics in orthopaedic surgery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423570/ https://www.ncbi.nlm.nih.gov/pubmed/28529861 http://dx.doi.org/10.7150/jbji.16649 |
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