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Use of Chlorhexidine Preparations in Total Joint Arthroplasty
Prosthetic joint infection (PJI) is a serious complication after total joint arthroplasty (TJA). Chlorhexidine is a widely used antiseptic because of its rapid and persistent action. It is well tolerated and available in different formulations at various concentrations. Chlorhexidine can be used for...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423571/ https://www.ncbi.nlm.nih.gov/pubmed/28529860 http://dx.doi.org/10.7150/jbji.16934 |
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author | George, Jaiben Klika, Alison K Higuera, Carlos A |
author_facet | George, Jaiben Klika, Alison K Higuera, Carlos A |
author_sort | George, Jaiben |
collection | PubMed |
description | Prosthetic joint infection (PJI) is a serious complication after total joint arthroplasty (TJA). Chlorhexidine is a widely used antiseptic because of its rapid and persistent action. It is well tolerated and available in different formulations at various concentrations. Chlorhexidine can be used for pre-operative skin cleansing, surgical site preparation, hand antisepsis of the surgical team and intra-articular irrigation of infected joints. The optimal intra-articular concentration of chlorhexidine gluconate in irrigation solution is 2%, to provide a persistent decrease in biofilm formation, though cytotoxicity might be an issue. Although chlorhexidine is relatively cheap, routine use of chlorhexidine without evidence of clear benefits can lead to unnecessary costs, adverse effects and even emergence of resistance. This review focuses on the current applications of various chlorhexidine formulations in TJA. As the treatment of PJI is challenging and expensive, effective preparations of chlorhexidine could help in the prevention and control of PJI. |
format | Online Article Text |
id | pubmed-5423571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-54235712017-05-19 Use of Chlorhexidine Preparations in Total Joint Arthroplasty George, Jaiben Klika, Alison K Higuera, Carlos A J Bone Jt Infect Review Prosthetic joint infection (PJI) is a serious complication after total joint arthroplasty (TJA). Chlorhexidine is a widely used antiseptic because of its rapid and persistent action. It is well tolerated and available in different formulations at various concentrations. Chlorhexidine can be used for pre-operative skin cleansing, surgical site preparation, hand antisepsis of the surgical team and intra-articular irrigation of infected joints. The optimal intra-articular concentration of chlorhexidine gluconate in irrigation solution is 2%, to provide a persistent decrease in biofilm formation, though cytotoxicity might be an issue. Although chlorhexidine is relatively cheap, routine use of chlorhexidine without evidence of clear benefits can lead to unnecessary costs, adverse effects and even emergence of resistance. This review focuses on the current applications of various chlorhexidine formulations in TJA. As the treatment of PJI is challenging and expensive, effective preparations of chlorhexidine could help in the prevention and control of PJI. Ivyspring International Publisher 2017-01-01 /pmc/articles/PMC5423571/ /pubmed/28529860 http://dx.doi.org/10.7150/jbji.16934 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review George, Jaiben Klika, Alison K Higuera, Carlos A Use of Chlorhexidine Preparations in Total Joint Arthroplasty |
title | Use of Chlorhexidine Preparations in Total Joint Arthroplasty |
title_full | Use of Chlorhexidine Preparations in Total Joint Arthroplasty |
title_fullStr | Use of Chlorhexidine Preparations in Total Joint Arthroplasty |
title_full_unstemmed | Use of Chlorhexidine Preparations in Total Joint Arthroplasty |
title_short | Use of Chlorhexidine Preparations in Total Joint Arthroplasty |
title_sort | use of chlorhexidine preparations in total joint arthroplasty |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423571/ https://www.ncbi.nlm.nih.gov/pubmed/28529860 http://dx.doi.org/10.7150/jbji.16934 |
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