Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature

Leptomeningeal metastases (LM) are found in approximately 3.8% of non-small cell lung cancer cases with an increased incidence in adenocarcinoma, and approximately one-third of patients will present with concomitant brain metastases. We report the case of a 50-year-old male patient with stage IV exo...

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Autores principales: Eze, Chukwuka, Hegemann, Nina-Sophie, Roengvoraphoj, Olarn, Dantes, Maurice, Manapov, Farkhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423895/
https://www.ncbi.nlm.nih.gov/pubmed/28540256
http://dx.doi.org/10.3389/fonc.2017.00088
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author Eze, Chukwuka
Hegemann, Nina-Sophie
Roengvoraphoj, Olarn
Dantes, Maurice
Manapov, Farkhad
author_facet Eze, Chukwuka
Hegemann, Nina-Sophie
Roengvoraphoj, Olarn
Dantes, Maurice
Manapov, Farkhad
author_sort Eze, Chukwuka
collection PubMed
description Leptomeningeal metastases (LM) are found in approximately 3.8% of non-small cell lung cancer cases with an increased incidence in adenocarcinoma, and approximately one-third of patients will present with concomitant brain metastases. We report the case of a 50-year-old male patient with stage IV exon 19-del-EGFR mutant lung adenocarcinoma who progressed on second-generation TKI therapy with manifestation of symptomatic simultaneous diffuse brain and LM. Whole-brain radiotherapy with concurrent afatinib resulted in an almost complete regression of neurological symptoms as well as good, durable radiological response. Furthermore, treatment was well tolerated with no relevant adverse effects.
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spelling pubmed-54238952017-05-24 Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature Eze, Chukwuka Hegemann, Nina-Sophie Roengvoraphoj, Olarn Dantes, Maurice Manapov, Farkhad Front Oncol Oncology Leptomeningeal metastases (LM) are found in approximately 3.8% of non-small cell lung cancer cases with an increased incidence in adenocarcinoma, and approximately one-third of patients will present with concomitant brain metastases. We report the case of a 50-year-old male patient with stage IV exon 19-del-EGFR mutant lung adenocarcinoma who progressed on second-generation TKI therapy with manifestation of symptomatic simultaneous diffuse brain and LM. Whole-brain radiotherapy with concurrent afatinib resulted in an almost complete regression of neurological symptoms as well as good, durable radiological response. Furthermore, treatment was well tolerated with no relevant adverse effects. Frontiers Media S.A. 2017-05-10 /pmc/articles/PMC5423895/ /pubmed/28540256 http://dx.doi.org/10.3389/fonc.2017.00088 Text en Copyright © 2017 Eze, Hegemann, Roengvoraphoj, Dantes and Manapov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Eze, Chukwuka
Hegemann, Nina-Sophie
Roengvoraphoj, Olarn
Dantes, Maurice
Manapov, Farkhad
Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature
title Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature
title_full Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature
title_fullStr Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature
title_full_unstemmed Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature
title_short Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature
title_sort concurrent afatinib and whole-brain radiotherapy in exon 19-del-egfr mutant lung adenocarcinoma: a case report and mini review of the literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423895/
https://www.ncbi.nlm.nih.gov/pubmed/28540256
http://dx.doi.org/10.3389/fonc.2017.00088
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