Cargando…

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes

Background and Aims: Hypoxia and oxidative stress contribute toward liver fibrosis. In this experiment, we used small hairpin RNA (shRNA) to interfere with the intracellular oxygen sensor—prolyl hydroxylase 1 (PHD1) and the intracellular oxidative stress sensor—kelch-like ECH associated protein 1 (K...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jing, Li, Yiping, Liu, Lei, Wang, Zhi, Shi, Chuanbing, Cheng, Zhengyuan, Zhang, Xiaoyi, Ding, Fengan, Chen, Ping Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423937/ https://www.ncbi.nlm.nih.gov/pubmed/28539891 http://dx.doi.org/10.3389/fphys.2017.00291

Ejemplares similares

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice
por: Liu, Jing, et al.
Publicado: (2018)

Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling
por: Wu, Haiyuan, et al.
Publicado: (2019)

Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss
por: Oishi, Tetsuya, et al.
Publicado: (2020)

Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids
por: Othman, Alaa, et al.
Publicado: (2023)

OGT-Mediated KEAP1 Glycosylation Accelerates NRF2 Degradation Leading to High Phosphate-Induced Vascular Calcification in Chronic Kidney Disease
por: Xu, Tian-Hua, et al.
Publicado: (2020)

Knockdown of CXCL1 improves ACLF by reducing neutrophil recruitment to attenuate ROS production and hepatocyte apoptosis
por: Tang, Shima, et al.
Publicado: (2023)

Exercise Attenuates Intermittent Hypoxia-Induced Cardiac Fibrosis Associated with Sodium-Hydrogen Exchanger-1 in Rats
por: Chen, Tsung-I, et al.
Publicado: (2016)

Methods for the Cost-Effective Production of Bacteria-Derived Double-Stranded RNA for in vitro Knockdown Studies
por: Verdonckt, Thomas-Wolf, et al.
Publicado: (2022)

Blueberry Polyphenol Extracts Enhance the Intestinal Antioxidant Capacity in Weaned Rats by Modulating the Nrf2–Keap1 Signal Pathway
por: Zhao, Fangfang, et al.
Publicado: (2021)

Knockdown of a Cyclic Nucleotide-Gated Ion Channel Impairs Locomotor Activity and Recovery From Hypoxia in Adult Drosophila melanogaster
por: Qiu, Shuang, et al.
Publicado: (2022)

Long Non-coding RNA MIAT Knockdown Prevents the Formation of Intracranial Aneurysm by Downregulating ENC1 via MYC
por: Li, Xinguo, et al.
Publicado: (2021)

Diminished Exercise Capacity and Mitochondrial bc1 Complex Deficiency in Tafazzin-Knockdown Mice
por: Powers, Corey, et al.
Publicado: (2013)

Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
por: Martin-Puig, Silvia, et al.
Publicado: (2015)

Caveolin-1 Impacts on TGF-β Regulation of Metabolic Gene Signatures in Hepatocytes
por: Han, Mei, et al.
Publicado: (2020)

Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish
por: Bian, Lixuan, et al.
Publicado: (2023)

Acute Exercise in Hypobaric Hypoxia Attenuates Endothelial Shedding in Subjects Unacclimatized to High Altitudes
por: Kröpfl, Julia M., et al.
Publicado: (2020)

HDL functionality is dependent on hepatocyte stress defense factors Nrf1 and Nrf2
por: Trites, Michael J., et al.
Publicado: (2023)

Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1
por: Liu, Minxuan, et al.
Publicado: (2020)

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
por: Adam, Julie, et al.
Publicado: (2011)

Muscle Oxygenation During Repeated Double-Poling Sprint Exercise in Normobaric Hypoxia and Normoxia
por: Yamaguchi, Keiichi, et al.
Publicado: (2019)

Metabolic Changes of Hepatocytes in NAFLD
por: Lu, Qianrang, et al.
Publicado: (2021)

Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner
por: Han, Xue, et al.
Publicado: (2016)

Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes
por: He, Juan, et al.
Publicado: (2019)

Gardenoside Hinders Caspase-1-Mediated Hepatocyte Pyroptosis Through the CTCF/DPP4 Signaling Pathway
por: Shen, Tian, et al.
Publicado: (2021)

Generation and characterization of keap1a- and keap1b-knockout zebrafish
por: Nguyen, Vu Thanh, et al.
Publicado: (2020)

Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes
por: Hwang, Sang Youn, et al.
Publicado: (2015)

Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity
por: Kim, Lenise J., et al.
Publicado: (2021)

PHD2: from hypoxia regulation to disease progression
por: Meneses, Ana M, et al.
Publicado: (2016)

Heavy Resistance Training in Hypoxia Enhances 1RM Squat Performance
por: Inness, Mathew W. H., et al.
Publicado: (2016)

Twin Resemblance in Muscle HIF-1α Responses to Hypoxia and Exercise
por: Van Thienen, Ruud, et al.
Publicado: (2017)

Enhancement of Glucose Metabolism via PGC-1α Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia
por: Li, Xuyi, et al.
Publicado: (2016)

The Autophagic Flux Inhibitor Bafilomycine A1 Affects the Expression of Intermediary Metabolism-Related Genes in Trout Hepatocytes
por: Séité, Sarah, et al.
Publicado: (2019)

Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio)
por: Wu, Liyun, et al.
Publicado: (2022)

Knockdown of carnitine palmitoyltransferase I (CPT1) reduces fat body lipid mobilization and resistance to starvation in the insect vector Rhodnius prolixus
por: De Paula, Iron F., et al.
Publicado: (2023)

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway
por: Li, Jiucui, et al.
Publicado: (2021)

Hepatocyte Ploidy Is a Diversity Factor for Liver Homeostasis
por: Kreutz, Clemens, et al.
Publicado: (2017)

Andrographolide Sulfonate Attenuates Acute Lung Injury by Reducing Expression of Myeloperoxidase and Neutrophil-Derived Proteases in Mice
por: Gao, Fei, et al.
Publicado: (2018)

Modulation of Muscle Fiber Compositions in Response to Hypoxia via Pyruvate Dehydrogenase Kinase-1
por: Nguyen, Daniel D., et al.
Publicado: (2016)

Malat1 deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli
por: Sallé-Lefort, Sandrine, et al.
Publicado: (2022)

Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxidative Stress in Drosophila melanogaster
por: Brischigliaro, Michele, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p2essel5rvvepk50dva1qvpleu