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Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns
Transcranial direct current stimulation (tDCS) is a widely-used tool to induce neuroplasticity and modulate cortical function by applying weak direct current over the scalp. In this review, we first introduce the underlying mechanism of action, the brief history from discovery to clinical scientific...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423956/ https://www.ncbi.nlm.nih.gov/pubmed/28539894 http://dx.doi.org/10.3389/fpsyg.2017.00685 |
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author | Zhao, Haichao Qiao, Lei Fan, Dongqiong Zhang, Shuyue Turel, Ofir Li, Yonghui Li, Jun Xue, Gui Chen, Antao He, Qinghua |
author_facet | Zhao, Haichao Qiao, Lei Fan, Dongqiong Zhang, Shuyue Turel, Ofir Li, Yonghui Li, Jun Xue, Gui Chen, Antao He, Qinghua |
author_sort | Zhao, Haichao |
collection | PubMed |
description | Transcranial direct current stimulation (tDCS) is a widely-used tool to induce neuroplasticity and modulate cortical function by applying weak direct current over the scalp. In this review, we first introduce the underlying mechanism of action, the brief history from discovery to clinical scientific research, electrode positioning and montages, and parameter setup of tDCS. Then, we review tDCS application in clinical samples including people with drug addiction, major depression disorder, Alzheimer's disease, as well as in children. This review covers the typical characteristics and the underlying neural mechanisms of tDCS treatment in such studies. This is followed by a discussion of safety, especially when the current intensity is increased or the stimulation duration is prolonged. Given such concerns, we provide detailed suggestions regarding safety procedures for tDCS operation. Lastly, future research directions are discussed. They include foci on the development of multi-tech combination with tDCS such as with TMS and fMRI; long-term behavioral and morphological changes; possible applications in other research domains, and more animal research to deepen the understanding of the biological and physiological mechanisms of tDCS stimulation. |
format | Online Article Text |
id | pubmed-5423956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54239562017-05-24 Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns Zhao, Haichao Qiao, Lei Fan, Dongqiong Zhang, Shuyue Turel, Ofir Li, Yonghui Li, Jun Xue, Gui Chen, Antao He, Qinghua Front Psychol Psychology Transcranial direct current stimulation (tDCS) is a widely-used tool to induce neuroplasticity and modulate cortical function by applying weak direct current over the scalp. In this review, we first introduce the underlying mechanism of action, the brief history from discovery to clinical scientific research, electrode positioning and montages, and parameter setup of tDCS. Then, we review tDCS application in clinical samples including people with drug addiction, major depression disorder, Alzheimer's disease, as well as in children. This review covers the typical characteristics and the underlying neural mechanisms of tDCS treatment in such studies. This is followed by a discussion of safety, especially when the current intensity is increased or the stimulation duration is prolonged. Given such concerns, we provide detailed suggestions regarding safety procedures for tDCS operation. Lastly, future research directions are discussed. They include foci on the development of multi-tech combination with tDCS such as with TMS and fMRI; long-term behavioral and morphological changes; possible applications in other research domains, and more animal research to deepen the understanding of the biological and physiological mechanisms of tDCS stimulation. Frontiers Media S.A. 2017-05-10 /pmc/articles/PMC5423956/ /pubmed/28539894 http://dx.doi.org/10.3389/fpsyg.2017.00685 Text en Copyright © 2017 Zhao, Qiao, Fan, Zhang, Turel, Li, Li, Xue, Chen and He. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Zhao, Haichao Qiao, Lei Fan, Dongqiong Zhang, Shuyue Turel, Ofir Li, Yonghui Li, Jun Xue, Gui Chen, Antao He, Qinghua Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns |
title | Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns |
title_full | Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns |
title_fullStr | Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns |
title_full_unstemmed | Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns |
title_short | Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns |
title_sort | modulation of brain activity with noninvasive transcranial direct current stimulation (tdcs): clinical applications and safety concerns |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423956/ https://www.ncbi.nlm.nih.gov/pubmed/28539894 http://dx.doi.org/10.3389/fpsyg.2017.00685 |
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