Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans

Human diseases of impaired ribosome biogenesis resulting from disruption of rRNA biosynthesis or loss of ribosomal components are collectively described as ‘ribosomopathies'. Treacher Collins syndrome (TCS), a representative human ribosomopathy with craniofacial abnormalities, is attributed to...

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Detalles Bibliográficos
Autores principales: Lee, C-C, Tsai, Y-T, Kao, C-W, Lee, L-W, Lai, H-J, Ma, T-H, Chang, Y-S, Yeh, N-H, Lo, S J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424100/
https://www.ncbi.nlm.nih.gov/pubmed/24722283
http://dx.doi.org/10.1038/cddis.2014.114

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