Constitutive expression of murine c-FLIP(R) causes autoimmunity in aged mice

Death receptor-mediated apoptosis is a key mechanism for the control of immune responses and dysregulation of this pathway may lead to autoimmunity. Cellular FLICE-inhibitory proteins (c-FLIPs) are known as inhibitors of death receptor-mediated apoptosis. The only short murine c-FLIP splice variant...

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Detalles Bibliográficos
Autores principales: Ewald, F, Annemann, M, Pils, M C, Plaza-Sirvent, C, Neff, F, Erck, C, Reinhold, D, Schmitz, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424115/
https://www.ncbi.nlm.nih.gov/pubmed/24722293
http://dx.doi.org/10.1038/cddis.2014.138

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