Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease

Elevated carbohydrate antigen 19-9 (CA19-9) beyond 1000 U/L occurs in nonneoplastic conditions which is causing questioning of the use of CA19-9 as a marker for screening. We report a case where a 51-year-old male with Mirrizi Syndrome (MS) presented with markedly increased CA19-9 level (4,618 U/mL)...

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Autores principales: Shah, Natasha, Tetangco, Eula, Arshad, Hafiz Muhammad Sharjeel, Raddawi, Hareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424187/
https://www.ncbi.nlm.nih.gov/pubmed/28529808
http://dx.doi.org/10.1155/2017/2416901
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author Shah, Natasha
Tetangco, Eula
Arshad, Hafiz Muhammad Sharjeel
Raddawi, Hareth
author_facet Shah, Natasha
Tetangco, Eula
Arshad, Hafiz Muhammad Sharjeel
Raddawi, Hareth
author_sort Shah, Natasha
collection PubMed
description Elevated carbohydrate antigen 19-9 (CA19-9) beyond 1000 U/L occurs in nonneoplastic conditions which is causing questioning of the use of CA19-9 as a marker for screening. We report a case where a 51-year-old male with Mirrizi Syndrome (MS) presented with markedly increased CA19-9 level (4,618 U/mL). MS is a rare complication characterized by compression of the common bile or hepatic duct caused by an impacted gallstone in the cystic duct or neck of the gallbladder. Biliary epithelial cells secrete CA19-9: it is hypothesized that increased proliferation of such cells caused by inflammation leads to increased secretion. CA19-9 should not be used as a diagnostic tool, but rather for surveillance.
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spelling pubmed-54241872017-05-21 Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease Shah, Natasha Tetangco, Eula Arshad, Hafiz Muhammad Sharjeel Raddawi, Hareth Case Rep Gastrointest Med Case Report Elevated carbohydrate antigen 19-9 (CA19-9) beyond 1000 U/L occurs in nonneoplastic conditions which is causing questioning of the use of CA19-9 as a marker for screening. We report a case where a 51-year-old male with Mirrizi Syndrome (MS) presented with markedly increased CA19-9 level (4,618 U/mL). MS is a rare complication characterized by compression of the common bile or hepatic duct caused by an impacted gallstone in the cystic duct or neck of the gallbladder. Biliary epithelial cells secrete CA19-9: it is hypothesized that increased proliferation of such cells caused by inflammation leads to increased secretion. CA19-9 should not be used as a diagnostic tool, but rather for surveillance. Hindawi 2017 2017-04-26 /pmc/articles/PMC5424187/ /pubmed/28529808 http://dx.doi.org/10.1155/2017/2416901 Text en Copyright © 2017 Natasha Shah et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shah, Natasha
Tetangco, Eula
Arshad, Hafiz Muhammad Sharjeel
Raddawi, Hareth
Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease
title Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease
title_full Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease
title_fullStr Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease
title_full_unstemmed Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease
title_short Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease
title_sort mirrizi syndrome and markedly elevated levels of carbohydrate antigen 19-9 in the absence of malignant disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424187/
https://www.ncbi.nlm.nih.gov/pubmed/28529808
http://dx.doi.org/10.1155/2017/2416901
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