Cargando…

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cambodia. Us...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dhingra, Satish K., Redhi, Devasha, Combrinck, Jill M., Yeo, Tomas, Okombo, John, Henrich, Philipp P., Cowell, Annie N., Gupta, Purva, Stegman, Matthew L., Hoke, Jonathan M., Cooper, Roland A., Winzeler, Elizabeth, Mok, Sachel, Egan, Timothy J., Fidock, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424201/ https://www.ncbi.nlm.nih.gov/pubmed/28487425 http://dx.doi.org/10.1128/mBio.00303-17

Ejemplares similares

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
por: Ross, Leila S., et al.
Publicado: (2018)

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages
por: Okombo, John, et al.
Publicado: (2022)

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness
por: Dhingra, Satish K., et al.
Publicado: (2019)

Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials
por: Wicht, Kathryn J, et al.
Publicado: (2022)

Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT
por: Kim, Jonathan, et al.
Publicado: (2019)

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
por: Gabryszewski, Stanislaw J., et al.
Publicado: (2016)

PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport
por: Gomez, Guillermo M., et al.
Publicado: (2023)

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum
por: Valderramos, Stephanie G., et al.
Publicado: (2010)

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1
por: Adjalley, Sophie H., et al.
Publicado: (2015)

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities
por: Pulcini, Serena, et al.
Publicado: (2015)

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers
por: Eastman, Richard T., et al.
Publicado: (2016)

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum
por: Sanchez, Cecilia P., et al.
Publicado: (2022)

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
por: Shafik, Sarah Heckmatt, et al.
Publicado: (2022)

Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology
por: Callaghan, Paul S., et al.
Publicado: (2016)

Investigation of the Plasmodium falciparum Food Vacuole through Inducible Expression of the Chloroquine Resistance Transporter (PfCRT)
por: Ehlgen, Florian, et al.
Publicado: (2012)

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles
por: Papakrivos, Janni, et al.
Publicado: (2012)

Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type
por: Sa, Juliana M, et al.
Publicado: (2010)

Factors associated with high prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in a rural and urban community of Ogun State, Nigeria
por: Soniran, Olajoju T., et al.
Publicado: (2017)

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion
por: Thornton, L. Brock, et al.
Publicado: (2019)

Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates
por: Foguim, Francis Tsombeng, et al.
Publicado: (2020)

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance
por: Kane, John, et al.
Publicado: (2023)

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
por: Veiga, M. Isabel, et al.
Publicado: (2016)

Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum
por: Gabryszewski, Stanislaw J., et al.
Publicado: (2016)

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance
por: Small-Saunders, Jennifer L., et al.
Publicado: (2022)

CRT-D or CRT-P in CRT-indicated patients?
por: Kaya, Adnan, et al.
Publicado: (2017)

Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases
por: Morahan, Belinda J., et al.
Publicado: (2020)

Reproductive and endocrine effects of artemisinin, piperaquine, and artemisinin-piperaquine combination in rats
por: Li, Xiaobo, et al.
Publicado: (2022)

Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing
por: Kanai, Mariko, et al.
Publicado: (2022)

CRT-D or CRT-P?: the endless debate!
por: Daubert, J Claude
Publicado: (2023)

The risk of ventricular arrhythmias in a Dutch CRT population: CRT-defibrillator versus CRT-pacemaker
por: ter Horst, I. A. H., et al.
Publicado: (2016)

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum
por: Rocamora, Frances, et al.
Publicado: (2021)

Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients
por: Wu, Wanting, et al.
Publicado: (2021)

The Knockout for G Protein-Coupled Receptor-Like PfSR25 Increases the Susceptibility of Malaria Parasites to the Antimalarials Lumefantrine and Piperaquine but Not to Medicine for Malaria Venture Compounds
por: Santos, Benedito M., et al.
Publicado: (2021)

Efficacy and Day 7 Plasma Piperaquine Concentrations in African Children Treated for Uncomplicated Malaria with Dihydroartemisinin-Piperaquine
por: Zongo, Issaka, et al.
Publicado: (2014)

The universal CRT controller
por: Lips, R
Publicado: (1984)

Role of echocardiography in CRT
por: Tayal, Bhupendar, et al.
Publicado: (2018)

Virtual Works for CRT()
por: Waksman, Ron
Publicado: (2021)

Prognosis of CRT-treated and CRT-untreated unselected population with LBBB in Stockholm County
por: Gatti, Paolo, et al.
Publicado: (2023)

Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children
por: Sundell, Kerstin, et al.
Publicado: (2015)

Pfcrt Gene in Plasmodium falciparum Field Isolates from Muzaffargarh, Pakistan
por: Sahar, Sumrin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7t7bn5ebt3vf3jb9purv7cjbr5