Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration

BACKGROUND: The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition in diverse cellular and genomic contexts, we engineered highly sensitive, real-t...

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Detalles Bibliográficos
Autores principales: Kannan, Manoj, Li, Jingfeng, Fritz, Sarah E., Husarek, Kathryn E., Sanford, Jonathan C., Sullivan, Teresa L., Tiwary, Pawan Kumar, An, Wenfeng, Boeke, Jef D., Symer, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424313/
https://www.ncbi.nlm.nih.gov/pubmed/28491150
http://dx.doi.org/10.1186/s13100-017-0091-2

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