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Anti-inflammatory effects of H(2)S during acute bacterial infection: a review
Hydrogen sulfide (H(2)S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human tissues. As demonstrated in recent studies, H(2)S is produced endogenously in response...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424385/ https://www.ncbi.nlm.nih.gov/pubmed/28490346 http://dx.doi.org/10.1186/s12967-017-1206-8 |
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author | Benedetti, Francesca Curreli, Sabrina Krishnan, Selvi Davinelli, Sergio Cocchi, Fiorenza Scapagnini, Giovanni Gallo, Robert C. Zella, Davide |
author_facet | Benedetti, Francesca Curreli, Sabrina Krishnan, Selvi Davinelli, Sergio Cocchi, Fiorenza Scapagnini, Giovanni Gallo, Robert C. Zella, Davide |
author_sort | Benedetti, Francesca |
collection | PubMed |
description | Hydrogen sulfide (H(2)S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human tissues. As demonstrated in recent studies, H(2)S is produced endogenously in response to different cellular stimuli and plays different roles in controlling a number of physiological responses. The precise role of H(2)S in inflammation is still largely unknown. In particular, the role of H(2)S in the regulation of the inflammatory response in acute and chronic infections is being actively investigated because of its potential therapeutic use. To study the effect of H(2)S as an anti-inflammatory mediator during bacterial infections, we developed an ex vivo model of primary cells and cell lines infected with Mycoplasma. Our data demonstrate a dichotomic effect of H(2)S on the NF-kB and Nrf-2 molecular pathways, which were inhibited and stimulated, respectively. |
format | Online Article Text |
id | pubmed-5424385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54243852017-05-10 Anti-inflammatory effects of H(2)S during acute bacterial infection: a review Benedetti, Francesca Curreli, Sabrina Krishnan, Selvi Davinelli, Sergio Cocchi, Fiorenza Scapagnini, Giovanni Gallo, Robert C. Zella, Davide J Transl Med Review Hydrogen sulfide (H(2)S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human tissues. As demonstrated in recent studies, H(2)S is produced endogenously in response to different cellular stimuli and plays different roles in controlling a number of physiological responses. The precise role of H(2)S in inflammation is still largely unknown. In particular, the role of H(2)S in the regulation of the inflammatory response in acute and chronic infections is being actively investigated because of its potential therapeutic use. To study the effect of H(2)S as an anti-inflammatory mediator during bacterial infections, we developed an ex vivo model of primary cells and cell lines infected with Mycoplasma. Our data demonstrate a dichotomic effect of H(2)S on the NF-kB and Nrf-2 molecular pathways, which were inhibited and stimulated, respectively. BioMed Central 2017-05-10 /pmc/articles/PMC5424385/ /pubmed/28490346 http://dx.doi.org/10.1186/s12967-017-1206-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Benedetti, Francesca Curreli, Sabrina Krishnan, Selvi Davinelli, Sergio Cocchi, Fiorenza Scapagnini, Giovanni Gallo, Robert C. Zella, Davide Anti-inflammatory effects of H(2)S during acute bacterial infection: a review |
title | Anti-inflammatory effects of H(2)S during acute bacterial infection: a review |
title_full | Anti-inflammatory effects of H(2)S during acute bacterial infection: a review |
title_fullStr | Anti-inflammatory effects of H(2)S during acute bacterial infection: a review |
title_full_unstemmed | Anti-inflammatory effects of H(2)S during acute bacterial infection: a review |
title_short | Anti-inflammatory effects of H(2)S during acute bacterial infection: a review |
title_sort | anti-inflammatory effects of h(2)s during acute bacterial infection: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424385/ https://www.ncbi.nlm.nih.gov/pubmed/28490346 http://dx.doi.org/10.1186/s12967-017-1206-8 |
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