Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

[Image: see text] Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful...

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Autores principales: Patil, Pravin, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424440/
https://www.ncbi.nlm.nih.gov/pubmed/28240545
http://dx.doi.org/10.1021/acscombsci.7b00033
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author Patil, Pravin
Kurpiewska, Katarzyna
Kalinowska-Tłuścik, Justyna
Dömling, Alexander
author_facet Patil, Pravin
Kurpiewska, Katarzyna
Kalinowska-Tłuścik, Justyna
Dömling, Alexander
author_sort Patil, Pravin
collection PubMed
description [Image: see text] Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.
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spelling pubmed-54244402017-05-11 Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction Patil, Pravin Kurpiewska, Katarzyna Kalinowska-Tłuścik, Justyna Dömling, Alexander ACS Comb Sci [Image: see text] Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design. American Chemical Society 2017-02-27 2017-05-08 /pmc/articles/PMC5424440/ /pubmed/28240545 http://dx.doi.org/10.1021/acscombsci.7b00033 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Patil, Pravin
Kurpiewska, Katarzyna
Kalinowska-Tłuścik, Justyna
Dömling, Alexander
Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
title Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
title_full Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
title_fullStr Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
title_full_unstemmed Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
title_short Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
title_sort ammonia-promoted one-pot tetrazolopiperidinone synthesis by ugi reaction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424440/
https://www.ncbi.nlm.nih.gov/pubmed/28240545
http://dx.doi.org/10.1021/acscombsci.7b00033
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AT kalinowskatłuscikjustyna ammoniapromotedonepottetrazolopiperidinonesynthesisbyugireaction
AT domlingalexander ammoniapromotedonepottetrazolopiperidinonesynthesisbyugireaction

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