A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N (6)-methyladenosine demethylase FTO

The AlkB family of nucleic acid demethylases are of intense biological and medical interest because of their roles in nucleic acid repair and epigenetic modification. However their functional and molecular mechanisms are unclear, hence, there is strong interest in developing selective inhibitors for...

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Detalles Bibliográficos
Autores principales: Toh, Joel D. W., Sun, Lingyi, Lau, Lisa Z. M., Tan, Jackie, Low, Joanne J. A., Tang, Colin W. Q., Cheong, Eleanor J. Y., Tan, Melissa J. H., Chen, Yun, Hong, Wanjin, Gao, Yong-Gui, Woon, Esther C. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424463/
https://www.ncbi.nlm.nih.gov/pubmed/28553460
http://dx.doi.org/10.1039/c4sc02554g

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