Building a central nervous system: The neural stem cell lineage revealed

Neural stem cells (NSCs) are a multipotent, self-renewing source of undifferentiated cells in the periventricular region of the mammalian central nervous system (CNS). Since their original discovery 25 years ago, much has been learned about their development, persistence, localization, properties an...

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Detalles Bibliográficos
Autores principales: Xu, Wenjun, Lakshman, Nishanth, Morshead, Cindi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424705/
https://www.ncbi.nlm.nih.gov/pubmed/28516107
http://dx.doi.org/10.1080/23262133.2017.1300037
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author Xu, Wenjun
Lakshman, Nishanth
Morshead, Cindi M.
author_facet Xu, Wenjun
Lakshman, Nishanth
Morshead, Cindi M.
author_sort Xu, Wenjun
collection PubMed
description Neural stem cells (NSCs) are a multipotent, self-renewing source of undifferentiated cells in the periventricular region of the mammalian central nervous system (CNS). Since their original discovery 25 years ago, much has been learned about their development, persistence, localization, properties and potential. Herein we discuss the current state of knowledge pertaining to neural stem cells with a focus on the lineage relationship between two NSC populations along the neuraxis and their regionally distinct niches in the CNS.
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spelling pubmed-54247052018-04-28 Building a central nervous system: The neural stem cell lineage revealed Xu, Wenjun Lakshman, Nishanth Morshead, Cindi M. Neurogenesis (Austin) Review Neural stem cells (NSCs) are a multipotent, self-renewing source of undifferentiated cells in the periventricular region of the mammalian central nervous system (CNS). Since their original discovery 25 years ago, much has been learned about their development, persistence, localization, properties and potential. Herein we discuss the current state of knowledge pertaining to neural stem cells with a focus on the lineage relationship between two NSC populations along the neuraxis and their regionally distinct niches in the CNS. Taylor & Francis 2017-04-28 /pmc/articles/PMC5424705/ /pubmed/28516107 http://dx.doi.org/10.1080/23262133.2017.1300037 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Xu, Wenjun
Lakshman, Nishanth
Morshead, Cindi M.
Building a central nervous system: The neural stem cell lineage revealed
title Building a central nervous system: The neural stem cell lineage revealed
title_full Building a central nervous system: The neural stem cell lineage revealed
title_fullStr Building a central nervous system: The neural stem cell lineage revealed
title_full_unstemmed Building a central nervous system: The neural stem cell lineage revealed
title_short Building a central nervous system: The neural stem cell lineage revealed
title_sort building a central nervous system: the neural stem cell lineage revealed
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424705/
https://www.ncbi.nlm.nih.gov/pubmed/28516107
http://dx.doi.org/10.1080/23262133.2017.1300037
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