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Strain phenomenon in protein aggregation: Interplay between sequence and conformation
Studies of yeast and mammalian prions introduced the idea that the protein aggregates can exist in multiple stable conformations that can be propagated by seeding. These conformational states (aka strains) were shown to have distinct physical (secondary structure, stability) and biological (cytotoxi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424784/ https://www.ncbi.nlm.nih.gov/pubmed/28516026 http://dx.doi.org/10.4161/idp.27130 |