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Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic condition

We tested the hypotheses that hypoxic stimulation enhances growth potentials of canine lymphoma cells by activating hypoxia-inducible factor 1α (HIF-1α), and that the hypoxia-activated prodrug (TH-302) inhibits growth potentials in the cells. We investigated how hypoxic culture affects the growth ra...

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Detalles Bibliográficos
Autores principales:	Yamazaki, Hiroki, Lai, Yu-Chang, Tateno, Morihiro, Setoguchi, Asuka, Goto-Koshino, Yuko, Endo, Yasuyuki, Nakaichi, Munekazu, Tsujimoto, Hajime, Miura, Naoki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425042/ https://www.ncbi.nlm.nih.gov/pubmed/28489881 http://dx.doi.org/10.1371/journal.pone.0177305

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