Telomeres and the natural lifespan limit in humans

An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natur...

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Autores principales: Steenstrup, Troels, Kark, Jeremy D., Verhulst, Simon, Thinggaard, Mikael, Hjelmborg, Jacob V. B., Dalgård, Christine, Kyvik, Kirsten Ohm, Christiansen, Lene, Mangino, Massimo, Spector, Timothy D., Petersen, Inge, Kimura, Masayuki, Benetos, Athanase, Labat, Carlos, Sinnreich, Ronit, Hwang, Shih-Jen, Levy, Daniel, Hunt, Steven C., Fitzpatrick, Annette L., Chen, Wei, Berenson, Gerald S., Barbieri, Michelangela, Paolisso, Giuseppe, Gadalla, Shahinaz M., Savage, Sharon A., Christensen, Kaare, Yashin, Anatoliy I., Arbeev, Konstantin G., Aviv, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425118/
https://www.ncbi.nlm.nih.gov/pubmed/28394764
http://dx.doi.org/10.18632/aging.101216
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author Steenstrup, Troels
Kark, Jeremy D.
Verhulst, Simon
Thinggaard, Mikael
Hjelmborg, Jacob V. B.
Dalgård, Christine
Kyvik, Kirsten Ohm
Christiansen, Lene
Mangino, Massimo
Spector, Timothy D.
Petersen, Inge
Kimura, Masayuki
Benetos, Athanase
Labat, Carlos
Sinnreich, Ronit
Hwang, Shih-Jen
Levy, Daniel
Hunt, Steven C.
Fitzpatrick, Annette L.
Chen, Wei
Berenson, Gerald S.
Barbieri, Michelangela
Paolisso, Giuseppe
Gadalla, Shahinaz M.
Savage, Sharon A.
Christensen, Kaare
Yashin, Anatoliy I.
Arbeev, Konstantin G.
Aviv, Abraham
author_facet Steenstrup, Troels
Kark, Jeremy D.
Verhulst, Simon
Thinggaard, Mikael
Hjelmborg, Jacob V. B.
Dalgård, Christine
Kyvik, Kirsten Ohm
Christiansen, Lene
Mangino, Massimo
Spector, Timothy D.
Petersen, Inge
Kimura, Masayuki
Benetos, Athanase
Labat, Carlos
Sinnreich, Ronit
Hwang, Shih-Jen
Levy, Daniel
Hunt, Steven C.
Fitzpatrick, Annette L.
Chen, Wei
Berenson, Gerald S.
Barbieri, Michelangela
Paolisso, Giuseppe
Gadalla, Shahinaz M.
Savage, Sharon A.
Christensen, Kaare
Yashin, Anatoliy I.
Arbeev, Konstantin G.
Aviv, Abraham
author_sort Steenstrup, Troels
collection PubMed
description An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the ‘telomeric brink’, which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.
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spelling pubmed-54251182017-05-11 Telomeres and the natural lifespan limit in humans Steenstrup, Troels Kark, Jeremy D. Verhulst, Simon Thinggaard, Mikael Hjelmborg, Jacob V. B. Dalgård, Christine Kyvik, Kirsten Ohm Christiansen, Lene Mangino, Massimo Spector, Timothy D. Petersen, Inge Kimura, Masayuki Benetos, Athanase Labat, Carlos Sinnreich, Ronit Hwang, Shih-Jen Levy, Daniel Hunt, Steven C. Fitzpatrick, Annette L. Chen, Wei Berenson, Gerald S. Barbieri, Michelangela Paolisso, Giuseppe Gadalla, Shahinaz M. Savage, Sharon A. Christensen, Kaare Yashin, Anatoliy I. Arbeev, Konstantin G. Aviv, Abraham Aging (Albany NY) Research Paper An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the ‘telomeric brink’, which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink. Impact Journals 2017-04-06 /pmc/articles/PMC5425118/ /pubmed/28394764 http://dx.doi.org/10.18632/aging.101216 Text en Copyright © 2017 Steenstrup et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Steenstrup, Troels
Kark, Jeremy D.
Verhulst, Simon
Thinggaard, Mikael
Hjelmborg, Jacob V. B.
Dalgård, Christine
Kyvik, Kirsten Ohm
Christiansen, Lene
Mangino, Massimo
Spector, Timothy D.
Petersen, Inge
Kimura, Masayuki
Benetos, Athanase
Labat, Carlos
Sinnreich, Ronit
Hwang, Shih-Jen
Levy, Daniel
Hunt, Steven C.
Fitzpatrick, Annette L.
Chen, Wei
Berenson, Gerald S.
Barbieri, Michelangela
Paolisso, Giuseppe
Gadalla, Shahinaz M.
Savage, Sharon A.
Christensen, Kaare
Yashin, Anatoliy I.
Arbeev, Konstantin G.
Aviv, Abraham
Telomeres and the natural lifespan limit in humans
title Telomeres and the natural lifespan limit in humans
title_full Telomeres and the natural lifespan limit in humans
title_fullStr Telomeres and the natural lifespan limit in humans
title_full_unstemmed Telomeres and the natural lifespan limit in humans
title_short Telomeres and the natural lifespan limit in humans
title_sort telomeres and the natural lifespan limit in humans
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425118/
https://www.ncbi.nlm.nih.gov/pubmed/28394764
http://dx.doi.org/10.18632/aging.101216
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