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The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in maintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal en...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425123/ https://www.ncbi.nlm.nih.gov/pubmed/28437249 http://dx.doi.org/10.18632/aging.101223 |
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author | Wagner, Kay-Dietrich Ying, Yilin Leong, Waiian Jiang, Jie Hu, Xuefei Chen, Yi Michiels, Jean-François Lu, Yiming Gilson, Eric Wagner, Nicole Ye, Jing |
author_facet | Wagner, Kay-Dietrich Ying, Yilin Leong, Waiian Jiang, Jie Hu, Xuefei Chen, Yi Michiels, Jean-François Lu, Yiming Gilson, Eric Wagner, Nicole Ye, Jing |
author_sort | Wagner, Kay-Dietrich |
collection | PubMed |
description | Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in maintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging. |
format | Online Article Text |
id | pubmed-5425123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54251232017-05-11 The differential spatiotemporal expression pattern of shelterin genes throughout lifespan Wagner, Kay-Dietrich Ying, Yilin Leong, Waiian Jiang, Jie Hu, Xuefei Chen, Yi Michiels, Jean-François Lu, Yiming Gilson, Eric Wagner, Nicole Ye, Jing Aging (Albany NY) Research Paper Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in maintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging. Impact Journals LLC 2017-04-17 /pmc/articles/PMC5425123/ /pubmed/28437249 http://dx.doi.org/10.18632/aging.101223 Text en Copyright: © 2017 Wagner et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Wagner, Kay-Dietrich Ying, Yilin Leong, Waiian Jiang, Jie Hu, Xuefei Chen, Yi Michiels, Jean-François Lu, Yiming Gilson, Eric Wagner, Nicole Ye, Jing The differential spatiotemporal expression pattern of shelterin genes throughout lifespan |
title | The differential spatiotemporal expression pattern of shelterin genes throughout lifespan |
title_full | The differential spatiotemporal expression pattern of shelterin genes throughout lifespan |
title_fullStr | The differential spatiotemporal expression pattern of shelterin genes throughout lifespan |
title_full_unstemmed | The differential spatiotemporal expression pattern of shelterin genes throughout lifespan |
title_short | The differential spatiotemporal expression pattern of shelterin genes throughout lifespan |
title_sort | differential spatiotemporal expression pattern of shelterin genes throughout lifespan |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425123/ https://www.ncbi.nlm.nih.gov/pubmed/28437249 http://dx.doi.org/10.18632/aging.101223 |
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