Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy

Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differen...

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Detalles Bibliográficos
Autores principales: Wong, Raymond C.B., Lim, Shiang Y., Hung, Sandy S.C., Jackson, Stacey, Khan, Shahnaz, Van Bergen, Nicole J., De Smit, Elisabeth, Liang, Helena H., Kearns, Lisa S, Clarke, Linda, Mackey, David A., Hewitt, Alex W., Trounce, Ian A., Pébay, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425131/
https://www.ncbi.nlm.nih.gov/pubmed/28455970
http://dx.doi.org/10.18632/aging.101231

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