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HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline

BACKGROUND: We have previously reported that persons co-infected with HIV and hepatitis C virus (HCV) had liver disease stages similar to HIV-uninfected individuals who were approximately 10 years older. Insulin-like growth factor 1(IGF-1) levels have long been known to decline with advancing age in...

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Autores principales: Quinn, Jeffrey, Astemborski, Jacquie, Mehta, Shruti H., Kirk, Gregory D., Thomas, David L., Balagopal, Ashwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pathogens and Immunity 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425162/
https://www.ncbi.nlm.nih.gov/pubmed/28503671
http://dx.doi.org/10.20411/pai.v2i1.183
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author Quinn, Jeffrey
Astemborski, Jacquie
Mehta, Shruti H.
Kirk, Gregory D.
Thomas, David L.
Balagopal, Ashwin
author_facet Quinn, Jeffrey
Astemborski, Jacquie
Mehta, Shruti H.
Kirk, Gregory D.
Thomas, David L.
Balagopal, Ashwin
author_sort Quinn, Jeffrey
collection PubMed
description BACKGROUND: We have previously reported that persons co-infected with HIV and hepatitis C virus (HCV) had liver disease stages similar to HIV-uninfected individuals who were approximately 10 years older. Insulin-like growth factor 1(IGF-1) levels have long been known to decline with advancing age in humans and non-humans alike. We examined whether HIV infection affects the expected decline in IGF-1 in persons with chronic hepatitis C virus (HCV) infection and if that alteration in IGF-1 decline contributes to the link between HIV, aging, and liver disease progression. METHODS: A total of 553 individuals with HCV infection were studied from the AIDS Linked to the Intravenous Experience (ALIVE) cohort for whom more than 10 years of follow-up was available. Serum IGF-1 levels were determined by ELISA and evaluated according to baseline characteristics and over time by HIV status and liver disease progression. Linear regression with generalized estimating equations was used to determine whether IGF-1 decline over time was independently associated with liver disease progression. RESULTS: Baseline IGF-1 levels were strongly associated with age (P < 0.0001) but not with gender or HIV infection. Levels of IGF-1 declined at a rate of -1.75 ng/mL each year in HCV mono-infected individuals and at a rate of -1.23 ng/mL each year in HIV/HCV co-infected individuals (P < 0.05). In a multivariable linear regression model, progression of liver fibrosis was associated with HIV infection and age, as well as with a slower rate of IGF-1 decline (P = 0.001); however, the rate of IGF-1 decline did not alter the strength of the associations between HIV, liver disease, and age. CONCLUSIONS: The normal decline in IGF-1 levels with age was attenuated in HIV/HCV co-infected individuals compared to those with HCV mono-infection, and slower IGF-1 decline was independently associated with liver disease progression.
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spelling pubmed-54251622017-05-10 HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline Quinn, Jeffrey Astemborski, Jacquie Mehta, Shruti H. Kirk, Gregory D. Thomas, David L. Balagopal, Ashwin Pathog Immun Research Article BACKGROUND: We have previously reported that persons co-infected with HIV and hepatitis C virus (HCV) had liver disease stages similar to HIV-uninfected individuals who were approximately 10 years older. Insulin-like growth factor 1(IGF-1) levels have long been known to decline with advancing age in humans and non-humans alike. We examined whether HIV infection affects the expected decline in IGF-1 in persons with chronic hepatitis C virus (HCV) infection and if that alteration in IGF-1 decline contributes to the link between HIV, aging, and liver disease progression. METHODS: A total of 553 individuals with HCV infection were studied from the AIDS Linked to the Intravenous Experience (ALIVE) cohort for whom more than 10 years of follow-up was available. Serum IGF-1 levels were determined by ELISA and evaluated according to baseline characteristics and over time by HIV status and liver disease progression. Linear regression with generalized estimating equations was used to determine whether IGF-1 decline over time was independently associated with liver disease progression. RESULTS: Baseline IGF-1 levels were strongly associated with age (P < 0.0001) but not with gender or HIV infection. Levels of IGF-1 declined at a rate of -1.75 ng/mL each year in HCV mono-infected individuals and at a rate of -1.23 ng/mL each year in HIV/HCV co-infected individuals (P < 0.05). In a multivariable linear regression model, progression of liver fibrosis was associated with HIV infection and age, as well as with a slower rate of IGF-1 decline (P = 0.001); however, the rate of IGF-1 decline did not alter the strength of the associations between HIV, liver disease, and age. CONCLUSIONS: The normal decline in IGF-1 levels with age was attenuated in HIV/HCV co-infected individuals compared to those with HCV mono-infection, and slower IGF-1 decline was independently associated with liver disease progression. Pathogens and Immunity 2017-03-03 /pmc/articles/PMC5425162/ /pubmed/28503671 http://dx.doi.org/10.20411/pai.v2i1.183 Text en © Pathogens and Immunity 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Research Article
Quinn, Jeffrey
Astemborski, Jacquie
Mehta, Shruti H.
Kirk, Gregory D.
Thomas, David L.
Balagopal, Ashwin
HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
title HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
title_full HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
title_fullStr HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
title_full_unstemmed HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
title_short HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
title_sort hiv/hcv co-infection, liver disease progression, and age-related igf-1 decline
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425162/
https://www.ncbi.nlm.nih.gov/pubmed/28503671
http://dx.doi.org/10.20411/pai.v2i1.183
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