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Structures of closed and open conformations of dimeric human ATM

ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase–related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is...

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Detalles Bibliográficos
Autores principales:	Baretić, Domagoj, Pollard, Hannah K., Fisher, David I., Johnson, Christopher M., Santhanam, Balaji, Truman, Caroline M., Kouba, Tomas, Fersht, Alan R., Phillips, Christopher, Williams, Roger L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425235/ https://www.ncbi.nlm.nih.gov/pubmed/28508083 http://dx.doi.org/10.1126/sciadv.1700933

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