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OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices
PURPOSE: To compare the quality of four OCT-angiography(OCT-A) modules. METHOD: The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). T...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425250/ https://www.ncbi.nlm.nih.gov/pubmed/28489918 http://dx.doi.org/10.1371/journal.pone.0177059 |
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author | Munk, Marion R. Giannakaki-Zimmermann, Helena Berger, Lieselotte Huf, Wolfgang Ebneter, Andreas Wolf, Sebastian Zinkernagel, Martin S. |
author_facet | Munk, Marion R. Giannakaki-Zimmermann, Helena Berger, Lieselotte Huf, Wolfgang Ebneter, Andreas Wolf, Sebastian Zinkernagel, Martin S. |
author_sort | Munk, Marion R. |
collection | PubMed |
description | PURPOSE: To compare the quality of four OCT-angiography(OCT-A) modules. METHOD: The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment, a consensus grading was performed and the modules were ranked based on their scoring. RESULTS: There was no significant difference in the vessel density among the modules (Zeiss 48.7±4%, Optovue 47.9±3%, Topcon 48.3±2%, Heidelberg 46.5±4%, p = 0.2). The numbers of discernible vessel-bifurcations differed significantly on each module (Zeiss 2±0.9 bifurcations, Optovue 2.5±1.2, Topcon 1.3±0.7 and Heidelberg 0.5±0.6, p≤0.001). The ranking of each module differed depending on the evaluated parameter. In the overall ranking, the Zeiss module was superior and in 90% better than the median (Bonferroni corrected p-value = 0.04). Optovue was better than the median in 60%, Topcon in 40% and Heidelberg module in 10%, however these differences were not statistically significant. CONCLUSION: Each of the four evaluated OCT-A modules had particular strengths, which differentiated it from their competitors. |
format | Online Article Text |
id | pubmed-5425250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54252502017-05-15 OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices Munk, Marion R. Giannakaki-Zimmermann, Helena Berger, Lieselotte Huf, Wolfgang Ebneter, Andreas Wolf, Sebastian Zinkernagel, Martin S. PLoS One Research Article PURPOSE: To compare the quality of four OCT-angiography(OCT-A) modules. METHOD: The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment, a consensus grading was performed and the modules were ranked based on their scoring. RESULTS: There was no significant difference in the vessel density among the modules (Zeiss 48.7±4%, Optovue 47.9±3%, Topcon 48.3±2%, Heidelberg 46.5±4%, p = 0.2). The numbers of discernible vessel-bifurcations differed significantly on each module (Zeiss 2±0.9 bifurcations, Optovue 2.5±1.2, Topcon 1.3±0.7 and Heidelberg 0.5±0.6, p≤0.001). The ranking of each module differed depending on the evaluated parameter. In the overall ranking, the Zeiss module was superior and in 90% better than the median (Bonferroni corrected p-value = 0.04). Optovue was better than the median in 60%, Topcon in 40% and Heidelberg module in 10%, however these differences were not statistically significant. CONCLUSION: Each of the four evaluated OCT-A modules had particular strengths, which differentiated it from their competitors. Public Library of Science 2017-05-10 /pmc/articles/PMC5425250/ /pubmed/28489918 http://dx.doi.org/10.1371/journal.pone.0177059 Text en © 2017 Munk et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Munk, Marion R. Giannakaki-Zimmermann, Helena Berger, Lieselotte Huf, Wolfgang Ebneter, Andreas Wolf, Sebastian Zinkernagel, Martin S. OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices |
title | OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices |
title_full | OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices |
title_fullStr | OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices |
title_full_unstemmed | OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices |
title_short | OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices |
title_sort | oct-angiography: a qualitative and quantitative comparison of 4 oct-a devices |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425250/ https://www.ncbi.nlm.nih.gov/pubmed/28489918 http://dx.doi.org/10.1371/journal.pone.0177059 |
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