Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation

The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple seri...

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Detalles Bibliográficos
Autores principales: Azzarelli, Roberta, Hurley, Christopher, Sznurkowska, Magdalena K., Rulands, Steffen, Hardwick, Laura, Gamper, Ivonne, Ali, Fahad, McCracken, Laura, Hindley, Christopher, McDuff, Fiona, Nestorowa, Sonia, Kemp, Richard, Jones, Kenneth, Göttgens, Berthold, Huch, Meritxell, Evan, Gerard, Simons, Benjamin D., Winton, Douglas, Philpott, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425251/
https://www.ncbi.nlm.nih.gov/pubmed/28457793
http://dx.doi.org/10.1016/j.devcel.2017.04.004

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