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Antitumor Activity of a Mesenchymal Stem Cell Line Stably Secreting a Tumor-Targeted TNF-Related Apoptosis-Inducing Ligand Fusion Protein

Mesenchymal stem cells (MSCs) are currently exploited as gene delivery systems for transient in situ expression of cancer therapeutics. As an alternative to the prevailing viral expression, we here describe a murine MSC line stably expressing a therapeutic protein for up to 42 passages, yet fully ma...

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Detalles Bibliográficos
Autores principales:	Marini, Irene, Siegemund, Martin, Hutt, Meike, Kontermann, Roland E., Pfizenmaier, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425590/ https://www.ncbi.nlm.nih.gov/pubmed/28553285 http://dx.doi.org/10.3389/fimmu.2017.00536

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