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Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, loo...

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Autores principales: Peana, Alessandra T., Sánchez-Catalán, María J., Hipólito, Lucia, Rosas, Michela, Porru, Simona, Bennardini, Federico, Romualdi, Patrizia, Caputi, Francesca F., Candeletti, Sanzio, Polache, Ana, Granero, Luis, Acquas, Elio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425597/
https://www.ncbi.nlm.nih.gov/pubmed/28553209
http://dx.doi.org/10.3389/fnbeh.2017.00081
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author Peana, Alessandra T.
Sánchez-Catalán, María J.
Hipólito, Lucia
Rosas, Michela
Porru, Simona
Bennardini, Federico
Romualdi, Patrizia
Caputi, Francesca F.
Candeletti, Sanzio
Polache, Ana
Granero, Luis
Acquas, Elio
author_facet Peana, Alessandra T.
Sánchez-Catalán, María J.
Hipólito, Lucia
Rosas, Michela
Porru, Simona
Bennardini, Federico
Romualdi, Patrizia
Caputi, Francesca F.
Candeletti, Sanzio
Polache, Ana
Granero, Luis
Acquas, Elio
author_sort Peana, Alessandra T.
collection PubMed
description After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic.
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spelling pubmed-54255972017-05-26 Mystic Acetaldehyde: The Never-Ending Story on Alcoholism Peana, Alessandra T. Sánchez-Catalán, María J. Hipólito, Lucia Rosas, Michela Porru, Simona Bennardini, Federico Romualdi, Patrizia Caputi, Francesca F. Candeletti, Sanzio Polache, Ana Granero, Luis Acquas, Elio Front Behav Neurosci Neuroscience After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic. Frontiers Media S.A. 2017-05-11 /pmc/articles/PMC5425597/ /pubmed/28553209 http://dx.doi.org/10.3389/fnbeh.2017.00081 Text en Copyright © 2017 Peana, Sánchez-Catalán, Hipólito, Rosas, Porru, Bennardini, Romualdi, Caputi, Candeletti, Polache, Granero and Acquas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Peana, Alessandra T.
Sánchez-Catalán, María J.
Hipólito, Lucia
Rosas, Michela
Porru, Simona
Bennardini, Federico
Romualdi, Patrizia
Caputi, Francesca F.
Candeletti, Sanzio
Polache, Ana
Granero, Luis
Acquas, Elio
Mystic Acetaldehyde: The Never-Ending Story on Alcoholism
title Mystic Acetaldehyde: The Never-Ending Story on Alcoholism
title_full Mystic Acetaldehyde: The Never-Ending Story on Alcoholism
title_fullStr Mystic Acetaldehyde: The Never-Ending Story on Alcoholism
title_full_unstemmed Mystic Acetaldehyde: The Never-Ending Story on Alcoholism
title_short Mystic Acetaldehyde: The Never-Ending Story on Alcoholism
title_sort mystic acetaldehyde: the never-ending story on alcoholism
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425597/
https://www.ncbi.nlm.nih.gov/pubmed/28553209
http://dx.doi.org/10.3389/fnbeh.2017.00081
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