PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

Although valproic acid (VPA), has been shown to induce neuronal differentiation of neural stem cells (NSCs), the underlying mechanisms remain poorly understood. Here we investigated if and how mammalian target of rapamycin (mTOR) signaling is involved in the neuronal differentiation of VPA-induced N...

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Detalles Bibliográficos
Autores principales: Zhang, Xi, He, Xiaosong, Li, Qingqing, Kong, Xuejian, Ou, Zhenri, Zhang, Le, Gong, Zhuo, Long, Dahong, Li, Jianhua, Zhang, Meng, Ji, Weidong, Zhang, Wenjuan, Xu, Liping, Xuan, Aiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425725/
https://www.ncbi.nlm.nih.gov/pubmed/28494938
http://dx.doi.org/10.1016/j.stemcr.2017.04.006

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