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MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1 diabetes (T1D) and experimental autoimmune uveoret...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425726/ https://www.ncbi.nlm.nih.gov/pubmed/28494937 http://dx.doi.org/10.1016/j.stemcr.2017.04.008 |
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author | Shigemoto-Kuroda, Taeko Oh, Joo Youn Kim, Dong-ki Jeong, Hyun Jeong Park, Se Yeon Lee, Hyun Ju Park, Jong Woo Kim, Tae Wan An, Su Yeon Prockop, Darwin J. Lee, Ryang Hwa |
author_facet | Shigemoto-Kuroda, Taeko Oh, Joo Youn Kim, Dong-ki Jeong, Hyun Jeong Park, Se Yeon Lee, Hyun Ju Park, Jong Woo Kim, Tae Wan An, Su Yeon Prockop, Darwin J. Lee, Ryang Hwa |
author_sort | Shigemoto-Kuroda, Taeko |
collection | PubMed |
description | Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1 diabetes (T1D) and experimental autoimmune uveoretinitis (EAU). Therefore, here, we investigated the therapeutic potential of MSC-derived EVs using our established mouse models for autoimmune diseases affecting the pancreas and the eye: T1D and EAU. The data demonstrate that MSC-derived EVs effectively prevent the onset of disease in both T1D and EAU. In addition, the mixed lymphocyte reaction assay with MSC-derived EVs indicated that EVs inhibit activation of antigen-presenting cells and suppress development of T helper 1 (Th1) and Th17 cells. These results raise the possibility that MSC-derived EVs may be an alternative to cell therapy for autoimmune disease prevention. |
format | Online Article Text |
id | pubmed-5425726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54257262017-05-17 MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis Shigemoto-Kuroda, Taeko Oh, Joo Youn Kim, Dong-ki Jeong, Hyun Jeong Park, Se Yeon Lee, Hyun Ju Park, Jong Woo Kim, Tae Wan An, Su Yeon Prockop, Darwin J. Lee, Ryang Hwa Stem Cell Reports Article Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1 diabetes (T1D) and experimental autoimmune uveoretinitis (EAU). Therefore, here, we investigated the therapeutic potential of MSC-derived EVs using our established mouse models for autoimmune diseases affecting the pancreas and the eye: T1D and EAU. The data demonstrate that MSC-derived EVs effectively prevent the onset of disease in both T1D and EAU. In addition, the mixed lymphocyte reaction assay with MSC-derived EVs indicated that EVs inhibit activation of antigen-presenting cells and suppress development of T helper 1 (Th1) and Th17 cells. These results raise the possibility that MSC-derived EVs may be an alternative to cell therapy for autoimmune disease prevention. Elsevier 2017-05-09 /pmc/articles/PMC5425726/ /pubmed/28494937 http://dx.doi.org/10.1016/j.stemcr.2017.04.008 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Shigemoto-Kuroda, Taeko Oh, Joo Youn Kim, Dong-ki Jeong, Hyun Jeong Park, Se Yeon Lee, Hyun Ju Park, Jong Woo Kim, Tae Wan An, Su Yeon Prockop, Darwin J. Lee, Ryang Hwa MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis |
title | MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis |
title_full | MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis |
title_fullStr | MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis |
title_full_unstemmed | MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis |
title_short | MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis |
title_sort | msc-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425726/ https://www.ncbi.nlm.nih.gov/pubmed/28494937 http://dx.doi.org/10.1016/j.stemcr.2017.04.008 |
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