Integrated Stress Response as a Therapeutic Target for CNS Injuries

Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with enco...

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Detalles Bibliográficos
Autores principales: Romero-Ramírez, Lorenzo, Nieto-Sampedro, Manuel, Barreda-Manso, M. Asunción
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425910/
https://www.ncbi.nlm.nih.gov/pubmed/28536699
http://dx.doi.org/10.1155/2017/6953156
Descripción
Sumario:Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with encouraging potential as therapeutic target for CNS injury repair. In this review, we will focus on the progress in understanding the role of the ISR and we will discuss the effects of various small molecules that target the ISR on different animal models of CNS injury.

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