Integrated Stress Response as a Therapeutic Target for CNS Injuries

Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with enco...

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Detalles Bibliográficos
Autores principales: Romero-Ramírez, Lorenzo, Nieto-Sampedro, Manuel, Barreda-Manso, M. Asunción
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425910/
https://www.ncbi.nlm.nih.gov/pubmed/28536699
http://dx.doi.org/10.1155/2017/6953156
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author Romero-Ramírez, Lorenzo
Nieto-Sampedro, Manuel
Barreda-Manso, M. Asunción
author_facet Romero-Ramírez, Lorenzo
Nieto-Sampedro, Manuel
Barreda-Manso, M. Asunción
author_sort Romero-Ramírez, Lorenzo
collection PubMed
description Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with encouraging potential as therapeutic target for CNS injury repair. In this review, we will focus on the progress in understanding the role of the ISR and we will discuss the effects of various small molecules that target the ISR on different animal models of CNS injury.
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spelling pubmed-54259102017-05-23 Integrated Stress Response as a Therapeutic Target for CNS Injuries Romero-Ramírez, Lorenzo Nieto-Sampedro, Manuel Barreda-Manso, M. Asunción Biomed Res Int Review Article Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with encouraging potential as therapeutic target for CNS injury repair. In this review, we will focus on the progress in understanding the role of the ISR and we will discuss the effects of various small molecules that target the ISR on different animal models of CNS injury. Hindawi 2017 2017-04-27 /pmc/articles/PMC5425910/ /pubmed/28536699 http://dx.doi.org/10.1155/2017/6953156 Text en Copyright © 2017 Lorenzo Romero-Ramírez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Romero-Ramírez, Lorenzo
Nieto-Sampedro, Manuel
Barreda-Manso, M. Asunción
Integrated Stress Response as a Therapeutic Target for CNS Injuries
title Integrated Stress Response as a Therapeutic Target for CNS Injuries
title_full Integrated Stress Response as a Therapeutic Target for CNS Injuries
title_fullStr Integrated Stress Response as a Therapeutic Target for CNS Injuries
title_full_unstemmed Integrated Stress Response as a Therapeutic Target for CNS Injuries
title_short Integrated Stress Response as a Therapeutic Target for CNS Injuries
title_sort integrated stress response as a therapeutic target for cns injuries
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425910/
https://www.ncbi.nlm.nih.gov/pubmed/28536699
http://dx.doi.org/10.1155/2017/6953156
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