Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair

Maternal separation (MS) in neonates can lead to intestinal injury. MS in neonatal mice disrupts mucosal morphology, induces colonic inflammation and increases trans-cellular permeability. Several studies indicate that intestinal epithelial stem cells are capable of initiating gut repair in a variet...

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Detalles Bibliográficos
Autores principales: Li, Bo, Lee, Carol, Filler, Tali, Hock, Alison, Wu, Richard You, Li, Qi, Chen, Shigang, Koike, Yuhki, Ip, Wan, Chi, Lijun, Zani-Ruttenstock, Elke, Määttänen, Pekka, Gonska, Tanja, Delgado-Olguin, Paul, Zani, Augusto, Sherman, Philip M., Pierro, Agostino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425914/
https://www.ncbi.nlm.nih.gov/pubmed/28492284
http://dx.doi.org/10.1038/srep46616

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