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Redox signaling in acute oxygen sensing

Acute oxygen (O(2)) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O(2)-sensitive glomus cells with O(2)-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K(+) chan...

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Autores principales: Gao, Lin, González-Rodríguez, Patricia, Ortega-Sáenz, Patricia, López-Barneo, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426049/
https://www.ncbi.nlm.nih.gov/pubmed/28476010
http://dx.doi.org/10.1016/j.redox.2017.04.033
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author Gao, Lin
González-Rodríguez, Patricia
Ortega-Sáenz, Patricia
López-Barneo, José
author_facet Gao, Lin
González-Rodríguez, Patricia
Ortega-Sáenz, Patricia
López-Barneo, José
author_sort Gao, Lin
collection PubMed
description Acute oxygen (O(2)) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O(2)-sensitive glomus cells with O(2)-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K(+) channels is the signal that triggers cell depolarization, transmitter release and activation of sensory fibers that stimulate the brainstem respiratory center to produce hyperventilation. The molecular mechanisms underlying O(2) sensing by glomus cells have, however, remained elusive. Here we discuss recent data demonstrating that ablation of mitochondrial Ndufs2 gene selectively abolishes sensitivity of glomus cells to hypoxia, maintaining responsiveness to hypercapnia or hypoglycemia. These data suggest that reactive oxygen species and NADH generated in mitochondrial complex I during hypoxia are signaling molecules that modulate membrane K(+) channels. We propose that the structural substrates for acute O(2) sensing in CB glomus cells are “O(2)-sensing microdomains” formed by mitochondria and neighboring K(+) channels in the plasma membrane.
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spelling pubmed-54260492017-05-17 Redox signaling in acute oxygen sensing Gao, Lin González-Rodríguez, Patricia Ortega-Sáenz, Patricia López-Barneo, José Redox Biol Review Article Acute oxygen (O(2)) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O(2)-sensitive glomus cells with O(2)-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K(+) channels is the signal that triggers cell depolarization, transmitter release and activation of sensory fibers that stimulate the brainstem respiratory center to produce hyperventilation. The molecular mechanisms underlying O(2) sensing by glomus cells have, however, remained elusive. Here we discuss recent data demonstrating that ablation of mitochondrial Ndufs2 gene selectively abolishes sensitivity of glomus cells to hypoxia, maintaining responsiveness to hypercapnia or hypoglycemia. These data suggest that reactive oxygen species and NADH generated in mitochondrial complex I during hypoxia are signaling molecules that modulate membrane K(+) channels. We propose that the structural substrates for acute O(2) sensing in CB glomus cells are “O(2)-sensing microdomains” formed by mitochondria and neighboring K(+) channels in the plasma membrane. Elsevier 2017-04-26 /pmc/articles/PMC5426049/ /pubmed/28476010 http://dx.doi.org/10.1016/j.redox.2017.04.033 Text en © 2017 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Gao, Lin
González-Rodríguez, Patricia
Ortega-Sáenz, Patricia
López-Barneo, José
Redox signaling in acute oxygen sensing
title Redox signaling in acute oxygen sensing
title_full Redox signaling in acute oxygen sensing
title_fullStr Redox signaling in acute oxygen sensing
title_full_unstemmed Redox signaling in acute oxygen sensing
title_short Redox signaling in acute oxygen sensing
title_sort redox signaling in acute oxygen sensing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426049/
https://www.ncbi.nlm.nih.gov/pubmed/28476010
http://dx.doi.org/10.1016/j.redox.2017.04.033
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