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Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy
Biomarkers to predict the altering physiological conditions over the period leading toward the ocular disorders are of major importance in therapeutics. Isolation and validation of the biomarkers specific to ocular diseases are a challenging task. Glaucoma is a neurodegenerative disease of the eye w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426123/ https://www.ncbi.nlm.nih.gov/pubmed/28440247 http://dx.doi.org/10.4103/ijo.IJO_866_16 |
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author | Nath, Madhu Halder, Nabanita Velpandian, Thirumurthy |
author_facet | Nath, Madhu Halder, Nabanita Velpandian, Thirumurthy |
author_sort | Nath, Madhu |
collection | PubMed |
description | Biomarkers to predict the altering physiological conditions over the period leading toward the ocular disorders are of major importance in therapeutics. Isolation and validation of the biomarkers specific to ocular diseases are a challenging task. Glaucoma is a neurodegenerative disease of the eye where the correlation of biomarkers in circulating fluid may be made specific for the eye. However, conditions such as wet age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR), circulating biomarkers might be having some degree of overlap with other conditions like cancer where a common factor such as angiogenesis is involved. Diabetes, a systemic disorder affecting the target organs such as eye, kidney, heart, and nervous system can be predicted using common circulating biomarkers. However, these markers need to be validated along with various stages of disease progression to enable the possibility of targeted pharmacological interventions apart from good glycemic control alone. This review compiles the attempts made to correlate such circulating biomarkers in the ocular conditions such as glaucoma, AMD, and DR in the search for a surrogate marker for diagnostic and prognostic value. To make biomarkers for the common convenience, genetic markers are excluded from this review. |
format | Online Article Text |
id | pubmed-5426123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54261232017-05-31 Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy Nath, Madhu Halder, Nabanita Velpandian, Thirumurthy Indian J Ophthalmol Symposium Biomarkers to predict the altering physiological conditions over the period leading toward the ocular disorders are of major importance in therapeutics. Isolation and validation of the biomarkers specific to ocular diseases are a challenging task. Glaucoma is a neurodegenerative disease of the eye where the correlation of biomarkers in circulating fluid may be made specific for the eye. However, conditions such as wet age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR), circulating biomarkers might be having some degree of overlap with other conditions like cancer where a common factor such as angiogenesis is involved. Diabetes, a systemic disorder affecting the target organs such as eye, kidney, heart, and nervous system can be predicted using common circulating biomarkers. However, these markers need to be validated along with various stages of disease progression to enable the possibility of targeted pharmacological interventions apart from good glycemic control alone. This review compiles the attempts made to correlate such circulating biomarkers in the ocular conditions such as glaucoma, AMD, and DR in the search for a surrogate marker for diagnostic and prognostic value. To make biomarkers for the common convenience, genetic markers are excluded from this review. Medknow Publications & Media Pvt Ltd 2017-03 /pmc/articles/PMC5426123/ /pubmed/28440247 http://dx.doi.org/10.4103/ijo.IJO_866_16 Text en Copyright: © 2017 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Symposium Nath, Madhu Halder, Nabanita Velpandian, Thirumurthy Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy |
title | Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy |
title_full | Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy |
title_fullStr | Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy |
title_full_unstemmed | Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy |
title_short | Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy |
title_sort | circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy |
topic | Symposium |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426123/ https://www.ncbi.nlm.nih.gov/pubmed/28440247 http://dx.doi.org/10.4103/ijo.IJO_866_16 |
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