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Evaluation of meibomian gland and tear film changes in patients with pterygium

BACKGROUND: Recent studies have demonstrated that pterygium has a close relationship with dry eye disease. This study is to determine abnormalities in meibomian gland and tear function in patients with pterygium and to assess the relationship between the variables. MATERIALS AND METHODS: Forty eyes...

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Autores principales: Ye, Fen, Zhou, Fen, Xia, Yuan, Zhu, Xiaomin, Wu, Yan, Huang, Zhenping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426129/
https://www.ncbi.nlm.nih.gov/pubmed/28440253
http://dx.doi.org/10.4103/ijo.IJO_743_16
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author Ye, Fen
Zhou, Fen
Xia, Yuan
Zhu, Xiaomin
Wu, Yan
Huang, Zhenping
author_facet Ye, Fen
Zhou, Fen
Xia, Yuan
Zhu, Xiaomin
Wu, Yan
Huang, Zhenping
author_sort Ye, Fen
collection PubMed
description BACKGROUND: Recent studies have demonstrated that pterygium has a close relationship with dry eye disease. This study is to determine abnormalities in meibomian gland and tear function in patients with pterygium and to assess the relationship between the variables. MATERIALS AND METHODS: Forty eyes from forty patients with primary nasal pterygium and forty eyes from forty volunteers without ocular pathologies were enrolled in this study. Ocular surface disease index scores, meibomian gland expression scores, lid margin abnormality scores, meiboscore, tear film breakup time (BUT), Schirmer test (SIT) value, and the lower tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) using Fourier domain optical coherence were performed. Analysis of variance was applied for intergroup comparisons. A statistical significance level of P < 0.05 was considered. RESULTS: Ocular symptom scores, BUT scores, lid margin abnormality, meibomian gland expression, and meiboscore were significantly higher in pterygium patients than in controls (P < 0.01 for all scores). However, the SIT scores, the lower TMH, TMD, and TMA values did not revealed a significant difference between two groups (all P > 0.05). Multivariate regression analysis demonstrated that meiboscore significantly correlated with ocular symptom scores, BUT, lid margin abnormality scores, and meibomian gland expression scores. CONCLUSIONS: Meibomian gland function may be altered in pterygium patients, which is associated with uncomfortable ocular symptoms. Being aware of meibomian gland changes seems essential to understand the complex relationship among pterygium, tear film functions, and ocular surface changes.
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spelling pubmed-54261292017-05-31 Evaluation of meibomian gland and tear film changes in patients with pterygium Ye, Fen Zhou, Fen Xia, Yuan Zhu, Xiaomin Wu, Yan Huang, Zhenping Indian J Ophthalmol Original Article BACKGROUND: Recent studies have demonstrated that pterygium has a close relationship with dry eye disease. This study is to determine abnormalities in meibomian gland and tear function in patients with pterygium and to assess the relationship between the variables. MATERIALS AND METHODS: Forty eyes from forty patients with primary nasal pterygium and forty eyes from forty volunteers without ocular pathologies were enrolled in this study. Ocular surface disease index scores, meibomian gland expression scores, lid margin abnormality scores, meiboscore, tear film breakup time (BUT), Schirmer test (SIT) value, and the lower tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) using Fourier domain optical coherence were performed. Analysis of variance was applied for intergroup comparisons. A statistical significance level of P < 0.05 was considered. RESULTS: Ocular symptom scores, BUT scores, lid margin abnormality, meibomian gland expression, and meiboscore were significantly higher in pterygium patients than in controls (P < 0.01 for all scores). However, the SIT scores, the lower TMH, TMD, and TMA values did not revealed a significant difference between two groups (all P > 0.05). Multivariate regression analysis demonstrated that meiboscore significantly correlated with ocular symptom scores, BUT, lid margin abnormality scores, and meibomian gland expression scores. CONCLUSIONS: Meibomian gland function may be altered in pterygium patients, which is associated with uncomfortable ocular symptoms. Being aware of meibomian gland changes seems essential to understand the complex relationship among pterygium, tear film functions, and ocular surface changes. Medknow Publications & Media Pvt Ltd 2017-03 /pmc/articles/PMC5426129/ /pubmed/28440253 http://dx.doi.org/10.4103/ijo.IJO_743_16 Text en Copyright: © 2017 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ye, Fen
Zhou, Fen
Xia, Yuan
Zhu, Xiaomin
Wu, Yan
Huang, Zhenping
Evaluation of meibomian gland and tear film changes in patients with pterygium
title Evaluation of meibomian gland and tear film changes in patients with pterygium
title_full Evaluation of meibomian gland and tear film changes in patients with pterygium
title_fullStr Evaluation of meibomian gland and tear film changes in patients with pterygium
title_full_unstemmed Evaluation of meibomian gland and tear film changes in patients with pterygium
title_short Evaluation of meibomian gland and tear film changes in patients with pterygium
title_sort evaluation of meibomian gland and tear film changes in patients with pterygium
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426129/
https://www.ncbi.nlm.nih.gov/pubmed/28440253
http://dx.doi.org/10.4103/ijo.IJO_743_16
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