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The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007
The incidence of drug-resistant tuberculosis (DR-TB) in pediatric populations is a critical indicator of national TB management and treatment strategies. Limited data exist regarding the rate of pediatric DR-TB. In this study, we aimed to analyze the status of DR-TB in Korean children from 2007 to 2...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426251/ https://www.ncbi.nlm.nih.gov/pubmed/28480653 http://dx.doi.org/10.3346/jkms.2017.32.6.954 |
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author | Kim, Hyun-Jung Yoon, Hyung Ho Eun, Byung Wook Ahn, Youngmin Ryoo, Sungweon Kim, Hee Jin |
author_facet | Kim, Hyun-Jung Yoon, Hyung Ho Eun, Byung Wook Ahn, Youngmin Ryoo, Sungweon Kim, Hee Jin |
author_sort | Kim, Hyun-Jung |
collection | PubMed |
description | The incidence of drug-resistant tuberculosis (DR-TB) in pediatric populations is a critical indicator of national TB management and treatment strategies. Limited data exist regarding the rate of pediatric DR-TB. In this study, we aimed to analyze the status of DR-TB in Korean children from 2007 to 2013. We analyzed specimens submitted to the Korean Institute of Tuberculosis using Mycobacterium tuberculosis culture and drug susceptibility tests (DSTs) from January 2007 through December 2013. Specimens from patients ≤ 19 years of age were included. Among the 2,690 cases, 297 cases were excluded because of insufficient data, leaving 2,393 cases for the final analysis. In total, resistance to one or more TB drugs was 13.5%. The resistance rates of each of the drugs were as follows: isoniazid (INH) 10.2%, rifampin (RFP) 5.1%, ethambutol (EMB) 3.7%, and pyrazinamide (PZA) 3.1%. The resistance rate of multidrug-resistant TB (MDR-TB) was 4.2%, and that of extensively drug-resistant TB (XDR-TB) was 0.8%. The overall drug resistance rate demonstrated significant increase throughout the study period (P < 0.001) but showed no significant difference compared to previous study from 1999 to 2007. The drug resistance rate of PZA in ≤ 15 years of age group was significantly greater than that of > 15 years (P < 0.001). The drug resistance rate has increased throughout the study period. |
format | Online Article Text |
id | pubmed-5426251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-54262512017-06-01 The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 Kim, Hyun-Jung Yoon, Hyung Ho Eun, Byung Wook Ahn, Youngmin Ryoo, Sungweon Kim, Hee Jin J Korean Med Sci Original Article The incidence of drug-resistant tuberculosis (DR-TB) in pediatric populations is a critical indicator of national TB management and treatment strategies. Limited data exist regarding the rate of pediatric DR-TB. In this study, we aimed to analyze the status of DR-TB in Korean children from 2007 to 2013. We analyzed specimens submitted to the Korean Institute of Tuberculosis using Mycobacterium tuberculosis culture and drug susceptibility tests (DSTs) from January 2007 through December 2013. Specimens from patients ≤ 19 years of age were included. Among the 2,690 cases, 297 cases were excluded because of insufficient data, leaving 2,393 cases for the final analysis. In total, resistance to one or more TB drugs was 13.5%. The resistance rates of each of the drugs were as follows: isoniazid (INH) 10.2%, rifampin (RFP) 5.1%, ethambutol (EMB) 3.7%, and pyrazinamide (PZA) 3.1%. The resistance rate of multidrug-resistant TB (MDR-TB) was 4.2%, and that of extensively drug-resistant TB (XDR-TB) was 0.8%. The overall drug resistance rate demonstrated significant increase throughout the study period (P < 0.001) but showed no significant difference compared to previous study from 1999 to 2007. The drug resistance rate of PZA in ≤ 15 years of age group was significantly greater than that of > 15 years (P < 0.001). The drug resistance rate has increased throughout the study period. The Korean Academy of Medical Sciences 2017-06 2017-04-14 /pmc/articles/PMC5426251/ /pubmed/28480653 http://dx.doi.org/10.3346/jkms.2017.32.6.954 Text en © 2017 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Hyun-Jung Yoon, Hyung Ho Eun, Byung Wook Ahn, Youngmin Ryoo, Sungweon Kim, Hee Jin The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 |
title | The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 |
title_full | The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 |
title_fullStr | The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 |
title_full_unstemmed | The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 |
title_short | The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007 |
title_sort | rate of drug-resistant tuberculosis in korean children and adolescents since 2007 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426251/ https://www.ncbi.nlm.nih.gov/pubmed/28480653 http://dx.doi.org/10.3346/jkms.2017.32.6.954 |
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