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Selective N-terminal functionalization of native peptides and proteins

We report an efficient, highly selective modification on the N-terminal amines of peptides and proteins using aldehyde derivatives via reductive alkylation. After modification of a library of unprotected peptides XYSKEASAL (X varies over 20 natural amino acids) by benzaldehyde at room temperature, p...

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Detalles Bibliográficos
Autores principales:	Chen, Diao, Disotuar, Maria M., Xiong, Xiaochun, Wang, Yuanxiang, Chou, Danny Hung-Chieh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426342/ https://www.ncbi.nlm.nih.gov/pubmed/28553506 http://dx.doi.org/10.1039/c6sc04744k

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