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The protecting-group free selective 3′-functionalization of nucleosides

The direct and chemoselective 3′-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discovery of a novel 3′-phosphorylamidation of therapeutic nucleoside analogues with DBU, we explored the mechanism of this rare selectivity through a combination of NMR spectrosc...

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Detalles Bibliográficos
Autores principales:	McCabe Dunn, Jamie M., Reibarkh, Mikhail, Sherer, Edward C., Orr, Robert K., Ruck, Rebecca T., Simmons, Bryon, Bellomo, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426439/ https://www.ncbi.nlm.nih.gov/pubmed/28553517 http://dx.doi.org/10.1039/c6sc05081f

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