Cargando…
Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure
Bisphenol A (BPA) is a monomer used in a polymerization reaction in the production of polycarbonate plastics. It has been used in many consumer products, including plastics, polyvinyl chloride, food packaging, dental sealants, and thermal receipts. However, there is little information available on t...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Toxicology
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426503/ https://www.ncbi.nlm.nih.gov/pubmed/28503266 http://dx.doi.org/10.5487/TR.2017.33.2.165 |
_version_ | 1783235491521363968 |
---|---|
author | Chung, Yong Hyun Han, Jeong Hee Lee, Sung-Bae Lee, Yong-Hoon |
author_facet | Chung, Yong Hyun Han, Jeong Hee Lee, Sung-Bae Lee, Yong-Hoon |
author_sort | Chung, Yong Hyun |
collection | PubMed |
description | Bisphenol A (BPA) is a monomer used in a polymerization reaction in the production of polycarbonate plastics. It has been used in many consumer products, including plastics, polyvinyl chloride, food packaging, dental sealants, and thermal receipts. However, there is little information available on the inhalation toxicity of BPA. Therefore, the aim of this study was to determine its inhalation toxicity and effects on the estrous cycle, spatial learning, and memory. Sprague-Dawley rats were exposed to 0, 10, 30, and 90 mg/m(3) BPA, 6 hr/day, 5 days/week for 8 weeks via whole-body inhalation. Mortality, clinical signs, body weight, hematology, serum chemistry, estrous cycle parameters, performance in the Morris water maze test, and organ weights, as well as gross and histopathological findings, were compared between the control and BPA exposure groups. Statistically significant changes were observed in serum chemistry and organ weights upon exposure to BPA. However, there was no BPA-related toxic effect on the body weight, food consumption, hematology, serum chemistry, organ weights, estrous cycle, performance in the Morris water maze test, or gross or histopathological lesions in any male or female rats in the BPA exposure groups. In conclusion, the results of this study suggested that the no observable adverse effect level (NOAEL) for BPA in rats is above 90 mg/m(3)/6 hr/day, 5 days/week upon 8-week exposure. Furthermore, BPA did not affect the estrous cycle, spatial learning, or memory in rats. |
format | Online Article Text |
id | pubmed-5426503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Society of Toxicology |
record_format | MEDLINE/PubMed |
spelling | pubmed-54265032017-05-12 Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure Chung, Yong Hyun Han, Jeong Hee Lee, Sung-Bae Lee, Yong-Hoon Toxicol Res Original Article Bisphenol A (BPA) is a monomer used in a polymerization reaction in the production of polycarbonate plastics. It has been used in many consumer products, including plastics, polyvinyl chloride, food packaging, dental sealants, and thermal receipts. However, there is little information available on the inhalation toxicity of BPA. Therefore, the aim of this study was to determine its inhalation toxicity and effects on the estrous cycle, spatial learning, and memory. Sprague-Dawley rats were exposed to 0, 10, 30, and 90 mg/m(3) BPA, 6 hr/day, 5 days/week for 8 weeks via whole-body inhalation. Mortality, clinical signs, body weight, hematology, serum chemistry, estrous cycle parameters, performance in the Morris water maze test, and organ weights, as well as gross and histopathological findings, were compared between the control and BPA exposure groups. Statistically significant changes were observed in serum chemistry and organ weights upon exposure to BPA. However, there was no BPA-related toxic effect on the body weight, food consumption, hematology, serum chemistry, organ weights, estrous cycle, performance in the Morris water maze test, or gross or histopathological lesions in any male or female rats in the BPA exposure groups. In conclusion, the results of this study suggested that the no observable adverse effect level (NOAEL) for BPA in rats is above 90 mg/m(3)/6 hr/day, 5 days/week upon 8-week exposure. Furthermore, BPA did not affect the estrous cycle, spatial learning, or memory in rats. Korean Society of Toxicology 2017-04 2017-04-15 /pmc/articles/PMC5426503/ /pubmed/28503266 http://dx.doi.org/10.5487/TR.2017.33.2.165 Text en Copyright © 2017 The Korean Society Of Toxicology http://creativecommons.org/licenses/by-nc/3.0 This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chung, Yong Hyun Han, Jeong Hee Lee, Sung-Bae Lee, Yong-Hoon Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure |
title | Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure |
title_full | Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure |
title_fullStr | Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure |
title_full_unstemmed | Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure |
title_short | Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure |
title_sort | inhalation toxicity of bisphenol a and its effect on estrous cycle, spatial learning, and memory in rats upon whole-body exposure |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426503/ https://www.ncbi.nlm.nih.gov/pubmed/28503266 http://dx.doi.org/10.5487/TR.2017.33.2.165 |
work_keys_str_mv | AT chungyonghyun inhalationtoxicityofbisphenolaanditseffectonestrouscyclespatiallearningandmemoryinratsuponwholebodyexposure AT hanjeonghee inhalationtoxicityofbisphenolaanditseffectonestrouscyclespatiallearningandmemoryinratsuponwholebodyexposure AT leesungbae inhalationtoxicityofbisphenolaanditseffectonestrouscyclespatiallearningandmemoryinratsuponwholebodyexposure AT leeyonghoon inhalationtoxicityofbisphenolaanditseffectonestrouscyclespatiallearningandmemoryinratsuponwholebodyexposure |