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Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models

BACKGROUND AND PURPOSE: Chronic alcohol intake associated with an inappropriate diet can cause lesions in multiple organs and tissues and complicate the tissue repair process. In a systematic review, we analyzed the relevance of alcohol and high fat consumption to cutaneous and repair, compared the...

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Autores principales: Rosa, Daiane Figueiredo, Sarandy, Mariáurea Matias, Novaes, Rômulo Dias, da Matta, Sérgio Luís Pinto, Gonçalves, Reggiani Vilela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426595/
https://www.ncbi.nlm.nih.gov/pubmed/28493875
http://dx.doi.org/10.1371/journal.pone.0176240
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author Rosa, Daiane Figueiredo
Sarandy, Mariáurea Matias
Novaes, Rômulo Dias
da Matta, Sérgio Luís Pinto
Gonçalves, Reggiani Vilela
author_facet Rosa, Daiane Figueiredo
Sarandy, Mariáurea Matias
Novaes, Rômulo Dias
da Matta, Sérgio Luís Pinto
Gonçalves, Reggiani Vilela
author_sort Rosa, Daiane Figueiredo
collection PubMed
description BACKGROUND AND PURPOSE: Chronic alcohol intake associated with an inappropriate diet can cause lesions in multiple organs and tissues and complicate the tissue repair process. In a systematic review, we analyzed the relevance of alcohol and high fat consumption to cutaneous and repair, compared the main methodologies used and the most important parameters tested. Preclinical investigations with murine models were assessed to analyze whether the current evidence support clinical trials. METHODS: The studies were selected from MEDLINE/PubMed and Scopus databases, according to Fig 1. All 15 identified articles had their data extracted. The reporting bias was investigated according to the ARRIVE (Animal Research: Reporting of in Vivo Experiments) strategy. RESULTS: In general, animals offered a high-fat diet and alcohol showed decreased cutaneous wound closure, delayed skin contraction, chronic inflammation and incomplete re-epithelialization. CONCLUSION: In further studies, standardized experimental design is needed to establish comparable study groups and advance the overall knowledge background, facilitating data translatability from animal models to human clinical conditions.
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spelling pubmed-54265952017-05-25 Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models Rosa, Daiane Figueiredo Sarandy, Mariáurea Matias Novaes, Rômulo Dias da Matta, Sérgio Luís Pinto Gonçalves, Reggiani Vilela PLoS One Research Article BACKGROUND AND PURPOSE: Chronic alcohol intake associated with an inappropriate diet can cause lesions in multiple organs and tissues and complicate the tissue repair process. In a systematic review, we analyzed the relevance of alcohol and high fat consumption to cutaneous and repair, compared the main methodologies used and the most important parameters tested. Preclinical investigations with murine models were assessed to analyze whether the current evidence support clinical trials. METHODS: The studies were selected from MEDLINE/PubMed and Scopus databases, according to Fig 1. All 15 identified articles had their data extracted. The reporting bias was investigated according to the ARRIVE (Animal Research: Reporting of in Vivo Experiments) strategy. RESULTS: In general, animals offered a high-fat diet and alcohol showed decreased cutaneous wound closure, delayed skin contraction, chronic inflammation and incomplete re-epithelialization. CONCLUSION: In further studies, standardized experimental design is needed to establish comparable study groups and advance the overall knowledge background, facilitating data translatability from animal models to human clinical conditions. Public Library of Science 2017-05-11 /pmc/articles/PMC5426595/ /pubmed/28493875 http://dx.doi.org/10.1371/journal.pone.0176240 Text en © 2017 Rosa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rosa, Daiane Figueiredo
Sarandy, Mariáurea Matias
Novaes, Rômulo Dias
da Matta, Sérgio Luís Pinto
Gonçalves, Reggiani Vilela
Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models
title Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models
title_full Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models
title_fullStr Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models
title_full_unstemmed Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models
title_short Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models
title_sort effect of a high-fat diet and alcohol on cutaneous repair: a systematic review of murine experimental models
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426595/
https://www.ncbi.nlm.nih.gov/pubmed/28493875
http://dx.doi.org/10.1371/journal.pone.0176240
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