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Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field
OBJECTIVE: This systematic review examines the efficacy of hyperbaric oxygen (HBO(2)) for traumatic brain injury (TBI) to make evidence-based recommendations for its application and future research. METHODS: A comprehensive search was conducted to identify studies through 2014. Methodological qualit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Aspen Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426690/ https://www.ncbi.nlm.nih.gov/pubmed/27603765 http://dx.doi.org/10.1097/HTR.0000000000000256 |
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author | Crawford, Cindy Teo, Lynn Yang, EunMee Isbister, Caitlin Berry, Kevin |
author_facet | Crawford, Cindy Teo, Lynn Yang, EunMee Isbister, Caitlin Berry, Kevin |
author_sort | Crawford, Cindy |
collection | PubMed |
description | OBJECTIVE: This systematic review examines the efficacy of hyperbaric oxygen (HBO(2)) for traumatic brain injury (TBI) to make evidence-based recommendations for its application and future research. METHODS: A comprehensive search was conducted to identify studies through 2014. Methodological quality was assessed and synthesis and interpretation of relevant data was performed. RESULTS: Twelve randomized trials were included. All mild TBI studies demonstrated minimal bias and no statistically significant differences between HBO(2) and sham arms. Statistically significant improvement occurred over time within both groups. Moderate-to-severe TBI studies were of mixed quality, with majority of results favoring HBO(2) compared with “standard care.” The placebo analysis conducted was limited by lack of details. CONCLUSIONS: For mild TBI, results indicate HBO(2) is no better than sham treatment. Improvements within both HBO(2) and sham groups cannot be ignored. For acute treatment of moderate-to-severe TBI, although methodology appears flawed across some studies, because of the complexity of brain injury, HBO(2) may be beneficial as a relatively safe adjunctive therapy if feasible. Further research should be considered to resolve the controversy surrounding this field, but only if methodological flaws are avoided and bias minimized. |
format | Online Article Text |
id | pubmed-5426690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Aspen Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54266902017-05-22 Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field Crawford, Cindy Teo, Lynn Yang, EunMee Isbister, Caitlin Berry, Kevin J Head Trauma Rehabil Original Articles OBJECTIVE: This systematic review examines the efficacy of hyperbaric oxygen (HBO(2)) for traumatic brain injury (TBI) to make evidence-based recommendations for its application and future research. METHODS: A comprehensive search was conducted to identify studies through 2014. Methodological quality was assessed and synthesis and interpretation of relevant data was performed. RESULTS: Twelve randomized trials were included. All mild TBI studies demonstrated minimal bias and no statistically significant differences between HBO(2) and sham arms. Statistically significant improvement occurred over time within both groups. Moderate-to-severe TBI studies were of mixed quality, with majority of results favoring HBO(2) compared with “standard care.” The placebo analysis conducted was limited by lack of details. CONCLUSIONS: For mild TBI, results indicate HBO(2) is no better than sham treatment. Improvements within both HBO(2) and sham groups cannot be ignored. For acute treatment of moderate-to-severe TBI, although methodology appears flawed across some studies, because of the complexity of brain injury, HBO(2) may be beneficial as a relatively safe adjunctive therapy if feasible. Further research should be considered to resolve the controversy surrounding this field, but only if methodological flaws are avoided and bias minimized. Aspen Publications 2017-05 2016-09-06 /pmc/articles/PMC5426690/ /pubmed/27603765 http://dx.doi.org/10.1097/HTR.0000000000000256 Text en © 2017 The Authors. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Original Articles Crawford, Cindy Teo, Lynn Yang, EunMee Isbister, Caitlin Berry, Kevin Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field |
title | Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field |
title_full | Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field |
title_fullStr | Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field |
title_full_unstemmed | Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field |
title_short | Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field |
title_sort | is hyperbaric oxygen therapy effective for traumatic brain injury? a rapid evidence assessment of the literature and recommendations for the field |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426690/ https://www.ncbi.nlm.nih.gov/pubmed/27603765 http://dx.doi.org/10.1097/HTR.0000000000000256 |
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