Cargando…

Characterizing the Hot Spots Involved in RON-MSPβ Complex Formation Using In Silico Alanine Scanning Mutagenesis and Molecular Dynamics Simulation

Purpose: Implication of protein-protein interactions (PPIs) in development of many diseases such as cancer makes them attractive for therapeutic intervention and rational drug design. RON (Recepteur d’Origine Nantais) tyrosine kinase receptor has gained considerable attention as promising target in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zarei, Omid, Hamzeh-Mivehroud, Maryam, Benvenuti, Silvia, Ustun-Alkan, Fulya, Dastmalchi, Siavoush
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Tabriz University of Medical Sciences 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426727/ https://www.ncbi.nlm.nih.gov/pubmed/28507948 http://dx.doi.org/10.15171/apb.2017.018

Ejemplares similares

A Simple and Rapid Protocol for Producing Yeast Extract from Saccharomyces cerevisiae Suitable for Preparing Bacterial Culture Media
por: Zarei, Omid, et al.
Publicado: (2016)

In silico Evaluation of Crosslinking Effects on Denaturant m (eq) values and ΔCp upon Protein Unfolding
por: Hamzeh-Mivehroud, Maryam, et al.
Publicado: (2012)

Expression and Biological Evaluation of an Engineered Recombinant L-asparaginase Designed by In Silico Method Based on Sequence of the Enzyme from Escherichia coli
por: Dastmalchi, Mahrokh, et al.
Publicado: (2023)

Comparison of Different 2D and 3D-QSAR Methods on Activity Prediction of Histamine H3 Receptor Antagonists
por: Dastmalchi, Siavoush, et al.
Publicado: (2012)

In-silico Investigation of Tubulin Binding Modes of a Series of Novel Antiproliferative Spiroisoxazoline Compounds Using Docking Studies
por: Abolhasani, Hoda, et al.
Publicado: (2015)

Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant Bacillus strain
por: Safary, Azam, et al.
Publicado: (2019)

Identification of Novel Mutations in Arabidopsis thaliana DOF 4.2 Coding Gene
por: Jamshidi Kandjani, Omid, et al.
Publicado: (2021)

An Alignment-Independent 3D-QSAR Study of FGFR2 Tyrosine Kinase Inhibitors
por: Jafari, Behzad, et al.
Publicado: (2017)

Prediction of Hot Spots at Myeloid Cell Leukemia-1–Inhibitor Interface Using Energy Estimation and Alanine Scanning Mutagenesis
por: Marimuthu, Parthiban, et al.
Publicado: (2018)

MSP-RON Pathway: Potential Regulator of Inflammation and Innate Immunity
por: Huang, Lingtong, et al.
Publicado: (2020)

ABS–Scan: In silico alanine scanning mutagenesis for binding site residues in protein–ligand complex
por: Anand, Praveen, et al.
Publicado: (2014)

Characterization of Novel Fragment Antibodies Against TNF-alpha Isolated Using Phage Display Technique
por: Alizadeha, Ali Akbar, et al.
Publicado: (2019)

The MSP‐RON axis stimulates cancer cell growth in models of triple negative breast cancer
por: Millar, Rhona, et al.
Publicado: (2020)

Expression, purification and DNA-binding properties of zinc finger domains of DOF proteins from Arabidopsis thaliana
por: Moghaddas Sani, Hakimeh, et al.
Publicado: (2018)

Drug Repurposing for Identification of S1P1 Agonists with Potential Application in Multiple Sclerosis Using In Silico Drug Design Approaches
por: Alizadeh, Ali Akbar, et al.
Publicado: (2023)

The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells
por: Feres, K.J., et al.
Publicado: (2008)

In silico design of graphene plasmonic hot-spots
por: Bonatti, Luca, et al.
Publicado: (2022)

MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC)
por: Li, Ce, et al.
Publicado: (2019)

Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors
por: Fukutani, Yosuke, et al.
Publicado: (2021)

A QSAR Study on the 4-Substituted Coumarins as Potent Tubulin Polymerization Inhibitors
por: Dinparast, Leila, et al.
Publicado: (2020)

In Silico Insights towards the Identification of NLRP3 Druggable Hot Spots
por: Mekni, Nedra, et al.
Publicado: (2019)

Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution
por: Tse, Amanda, et al.
Publicado: (2015)

Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
por: Braun, Simon, et al.
Publicado: (2018)

Expression, Purification and Characterization of Functional Teduglutide Using GST Fusion System in Prokaryotic Cells
por: Alizadeh, Ali Akbar, et al.
Publicado: (2023)

Hot Spots and Their Contribution to the Self-Assembly of the Viral Capsid: In Silico Prediction and Analysis
por: Díaz-Valle, Armando, et al.
Publicado: (2019)

Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation
por: Duan, Chaohui, et al.
Publicado: (2012)

Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor
por: Ning, Jiong, et al.
Publicado: (2018)

Alanine Scanning Mutagenesis of the DRYxxI Motif and Intracellular Loop 2 of Human Melanocortin-4 Receptor
por: Yang, Li-Kun, et al.
Publicado: (2020)

Application of Carbonic Nanosheets Based on Urea Precursors as Dispersive Solid Phase Extraction Adsorbent for Extraction of Methamphetamine from Urine Samples
por: Taghvimi, Arezou, et al.
Publicado: (2021)

In silico prediction of immune-escaping hot spots for future COVID-19 vaccine design
por: Huang, Sing-Han, et al.
Publicado: (2023)

L-Alanine Prototrophic Suppressors Emerge from L-Alanine Auxotroph through Stress-Induced Mutagenesis in Escherichia coli
por: Mishima, Harutaka, et al.
Publicado: (2021)

Qingchang Wenzhong Decoction Attenuates DSS-Induced Colitis in Rats by Reducing Inflammation and Improving Intestinal Barrier Function via Upregulating the MSP/RON Signalling Pathway
por: Mao, Tangyou, et al.
Publicado: (2017)

Ron Knockdown and Ron Monoclonal Antibody IMC-RON8 Sensitize Pancreatic Cancer to Histone Deacetylase Inhibitors (HDACi)
por: Zou, Yi, et al.
Publicado: (2013)

Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis
por: Nakayama, Takayuki, et al.
Publicado: (2008)

Alanine-scanning mutagenesis of protein mannosyl-transferase from Streptomyces coelicolor reveals strong activity-stability correlation
por: Holman, Nathaniel D. M., et al.
Publicado: (2021)

Alignment independent 3D-QSAR studies and molecular dynamics simulations for the identification of potent and selective S1P(1) receptor agonists
por: Alizadeh, Ali Akbar, et al.
Publicado: (2020)

Preparation and Antiproliferative Activity Evaluation of Juglone-Loaded BSA Nanoparticles
por: Jahanban-Esfahlan, Ali, et al.
Publicado: (2022)

6D-QSAR for predicting biological activity of human aldose reductase inhibitors using quasar receptor surface modeling
por: Sokouti, Babak, et al.
Publicado: (2023)

circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts
por: Zhang, Yonggang, et al.
Publicado: (2020)

Bulevar del ron
por: Pécheral, Jacques R. (Jacques Renaud), 1908-
Publicado: (1966)

Cannot write session to /tmp/vufind_sessions/sess_4m7elpajdk5i4g8dvb7h75pce1